Loss of bone mineral density and trabecular bone score in elderly hemodialysis patients: a 2-year follow-up, prospective, single-centre study
| العنوان: | Loss of bone mineral density and trabecular bone score in elderly hemodialysis patients: a 2-year follow-up, prospective, single-centre study |
|---|---|
| المؤلفون: | Renata Lažanská, Petr Kasalický, Jana Verešová, Ludmila Brunerová, Ivan Rychlik, Jana Potockova |
| المصدر: | International Urology and Nephrology. 52:379-385 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Urology, medicine.medical_treatment, Population, 030232 urology & nephrology, Hemodiafiltration, 030204 cardiovascular system & hematology, 03 medical and health sciences, Absorptiometry, Photon, Sex Factors, 0302 clinical medicine, Trabecular bone score, Bone Density, Risk Factors, Humans, Medicine, Prospective Studies, education, Dialysis, Aged, Femoral neck, Aged, 80 and over, Bone mineral, education.field_of_study, Lumbar Vertebrae, Femur Neck, business.industry, Age Factors, Middle Aged, musculoskeletal system, medicine.anatomical_structure, Nephrology, Cancellous Bone, Cohort, Kidney Failure, Chronic, Osteoporosis, Calcium, Female, Hemodialysis, business, Densitometry, Osteoporotic Fractures, Follow-Up Studies |
| الوصف: | Low bone mineral density (BMD) and trabecular bone score (TBS) are established risk factors for fractures even in hemodialysis population and they seem to be significantly lower in comparison with general population. The aim of our study was to describe 2-year loss of BMD and TBS and their predictors in hemodialysis patients. From 59 non-selected patients (mean age 67.6 ± 13.1 years) from one dialysis centre, treated with hemodiafiltration (HDF), clinical and laboratory characteristics were obtained and densitometry examinations (with BMD and TBS results) were performed initially and at the end of 2-year follow-up. Two-year decrease in BMD of lumbar spine reached 4.1% (ns), of proximal femur 9.1% (p = 0.004), and of femoral neck 1.3% (ns). In the co-educated cohort, BMD decrease in all the sites correlated significantly with age and only the change of BMD of lumbar spine was negatively associated with serum calcium (r = − 0.39; p = 0.04) and dialysis vintage (r = − 0.387; p = 0.062), no other predictors of BMD loss were identified. Some predictors of BMD loss were identified with regard to gender. TBS decrease was 0.05 (3.9%; p = 0.03), and similarly, it was not predicted by any of selected parameters. No differences in BMD changes or TBS were observed between the patients with and without fractures. In patients with HDF, significant BMD and TBS annual losses were observed, and they were associated only with age and (in BMD of lumbar spine) with serum calcium and dialysis vintage. |
| تدمد: | 1573-2584 0301-1623 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2847bc22a4d49e512f687cd41cbb8a5bTest https://doi.org/10.1007/s11255-020-02378-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2847bc22a4d49e512f687cd41cbb8a5b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732584 03011623 |
|---|