In Vitro and In Vivo Effects of the Urokinase Plasminogen Activator Inhibitor WX-340 on Anaplastic Thyroid Cancer Cell Lines
| العنوان: | In Vitro and In Vivo Effects of the Urokinase Plasminogen Activator Inhibitor WX-340 on Anaplastic Thyroid Cancer Cell Lines |
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| المؤلفون: | Enke Baldini, Dario Presutti, Pasqualino Favoriti, Simonetta Santini, Giuliana Papoff, Chiara Tuccilli, Raffaella Carletti, Cira Di Gioia, Eleonora Lori, Iulia Catalina Ferent, Federica Gagliardi, Antonio Catania, Daniele Pironi, Domenico Tripodi, Vito D’Andrea, Salvatore Sorrenti, Giovina Ruberti, Salvatore Ulisse |
| المصدر: | International journal of molecular sciences (Online) (2022). doi:10.3390/ijms23073724 info:cnr-pdr/source/autori:Enke Baldini 1, Dario Presutti 2, Pasqualino Favoriti 1, Simonetta Santini 2, Giuliana Papoff 2, Chiara Tuccilli 1, Raffaella Carletti 3, Cira Di Gioia 3, Eleonora Lori 1, Iulia Catalina Ferent 1, Federica Gagliardi 1, Antonio Catania 1, Daniele Pironi 1, Domenico Tripodi 1, Vito D'Andrea 1, Salvatore Sorrenti 1, Giovina Ruberti 2 and Salvatore Ulisse 1/titolo:In Vitro and In Vivo Effects of the Urokinase Plasminogen Activator Inhibitor WX-340 on Anaplastic Thyroid Cancer Cell Lines/doi:10.3390%2Fijms23073724/rivista:International journal of molecular sciences (Online)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3724 |
| بيانات النشر: | MDPI Center, Basel (Sängergasse 25), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | cell migration, proliferation, anaplastic thyroid cancer, urokinase plasminogen activator, WX-340, xenograft, cell adhesion, BHT-101, CAL-62, Thyroid Carcinoma, Anaplastic, Peptides, Cyclic, Catalysis, anaplastic, Cell Line, Inorganic Chemistry, Plasminogen Activator Inhibitor 1, Plasminogen Activator Inhibitor 2, cell line, humans, neoplasm invasiveness, peptides, cyclic, plasminogen activator inhibitor 1, plasminogen activator inhibitor 2, urokinase-type plasminogen activator, thyroid carcinoma, anaplastic, thyroid neoplasms, Humans, Neoplasm Invasiveness, Thyroid Neoplasms, Physical and Theoretical Chemistry, cyclic, Molecular Biology, Spectroscopy, Organic Chemistry, General Medicine, thyroid carcinoma, Urokinase-Type Plasminogen Activator, Computer Science Applications, peptides |
| الوصف: | Increased expression of the urokinase-type plasminogen activator (uPA) system is associated with tumor invasion, neo-angiogenesis, and metastatic spread, and has been shown to positively correlate with a poor prognosis in several cancer types, including thyroid carcinomas. In recent years, several uPA inhibitors were found to have anticancer effects in preclinical studies and in some phase II clinical trials, which prompted us to evaluate uPA as a potential therapeutic target for the treatment of patients affected by the most aggressive form of thyroid cancer, the anaplastic thyroid carcinoma (ATC). In this study, we evaluated the in vitro and in vivo effects of WX-340, a highly specific and selective uPA inhibitor, on two ATC-derived cell lines, CAL-62 and BHT-101. The results obtained indicated that WX-340 was able to reduce cell adhesion and invasiveness in a dose-dependent manner in both cell lines. In addition, WX-340 increased uPA receptor (uPAR) protein levels without affecting its plasma membrane concentration. However, this compound was unable to significantly reduce ATC growth in a xenograft model, indicating that uPA inhibition alone may not have the expected therapeutic effects. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26917e84c1538cd593c7ef9522ba7ee2Test https://www.mdpi.com/1422-0067/23/7/3724/htmTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26917e84c1538cd593c7ef9522ba7ee2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |