Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium
| العنوان: | Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium |
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| المؤلفون: | Nivonirina Robinot, Andreana N. Holowatyj, Alexis Ulrich, Audrey Gicquiau, Annaleen Koole, Arve Ulvik, Augustin Scalbert, Tengda Lin, Jennifer Ose, Pekka Keski-Rahkonen, Per-Magne Ueland, Martin Schneider, Biljana Gigic, Matty P. Weijenberg, David Achaintre, Eline van van Roekel, Cornelia M. Ulrich, Anne J.M.R. Geijsen, Tanja Gumpenberger, Fränzel J.B. Van Duijnhoven, Andreas Baierl, Andrea Gsur, Dieuwertje E. Kok, Petra Schrotz-King, Stefanie Brezina, Nina Habermann |
| المساهمون: | RS: GROW - R1 - Prevention, Epidemiologie |
| المصدر: | Metabolites, 11(3), 1-16 Metabolites Volume 11 Issue 3 Metabolites, Vol 11, Iss 129, p 129 (2021) Metabolites, 11(3):129. Multidisciplinary Digital Publishing Institute (MDPI) Metabolites 11 (2021) 3 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute (MDPI), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, False discovery rate, Oncology, medicine.medical_specialty, recurrence, Nutrition and Disease, Colorectal cancer, Endocrinology, Diabetes and Metabolism, lcsh:QR1-502, colorectal cancer, Stage ii, Biochemistry, lcsh:Microbiology, Article, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, Recurrence, Internal medicine, Voeding en Ziekte, COLON, medicine, targeted metabolomics, Prospective cohort study, Molecular Biology, business.industry, Targeted metabolomics, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Cohort, Multiple comparisons problem, SURVIVAL, LIFE-STYLE, business, Body mass index |
| الوصف: | The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15%) had a recurrence after a median follow-up time of 20 months. We identified 13 metabolites that were nominally associated with a reduced risk of recurrence. None of the associations were statistically significant after controlling for multiple testing. Pathway topology analyses did not reveal statistically significant associations between recurrence and alterations in metabolic pathways (e.g., sphingolipid metabolism p = 0.04 pFDR = 1.00). To conclude, we did not observe statistically significant associations between metabolites and CRC recurrence using a well-established metabolomics assay. The observed results require follow-up in larger studies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2218-1989 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266cbb2950fe62f463fc7041040fa817Test https://cris.maastrichtuniversity.nl/en/publications/98db5a2b-27a1-4429-b6b3-a8a5b33f391eTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....266cbb2950fe62f463fc7041040fa817 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22181989 |
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