Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy
| العنوان: | Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy |
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| المؤلفون: | Gianfranco Pasut, Frances Beards, Francesca Greco, Abbie Dodd, Az Alddien Natfji, Antonella Grigoletto, Lewis Renshall, Lynda K. Harris, Helen M. I. Osborn, Angelos Evangelinos |
| المصدر: | Molecular Pharmaceutics. 19:345-353 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Basal rate, Polymers, Drug Compounding, Placenta, Pharmaceutical Science, Pharmacology, Polyethylene Glycols, Human chorionic gonadotropin, chemistry.chemical_compound, Pregnancy, Lactate dehydrogenase, Drug Discovery, PEG ratio, drug delivery, PEG, placenta, polymer−drug conjugate, pregnancy, transport, Haloperidol, medicine, Humans, Chemistry, technology, industry, and agriculture, Pregnancy Complications, medicine.anatomical_structure, Apoptosis, embryonic structures, Drug delivery, Molecular Medicine, Female, medicine.drug |
| الوصف: | Here, we evaluated the feasibility of non-prodrug PEG-drug conjugates to decrease the accumulation of drugs within the placental tissues. The results showed that PEG was biocompatible with the human placenta with no alteration of the basal rate of proliferation or apoptosis in term placental explants. No significant changes in the released levels of lactate dehydrogenase and the human chorionic gonadotropin were observed after PEG treatment. The cellular uptake studies revealed that conjugating Cy5.5 and haloperidol to PEG significantly reduced (by up to ∼40-fold) their uptake by the placenta. These findings highlight the viability of novel non-prodrug polymer-drug conjugates to avoid the accumulation of drugs within the placenta. |
| وصف الملف: | application/pdf |
| تدمد: | 1543-8392 1543-8384 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2666a0c847581476cb6e3b341d4656e7Test https://doi.org/10.1021/acs.molpharmaceut.1c00498Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2666a0c847581476cb6e3b341d4656e7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15438392 15438384 |
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