Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation
| العنوان: | Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation |
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| المؤلفون: | Jan P. M. Langeveld, Ronald S. Boshuizen, Alun Williams, Clive Bate |
| المصدر: | NeuroReport, 13(13), 1695-1700 NeuroReport 13 (2002) 13 |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Central Nervous System, Programmed cell death, Time Factors, Cell Survival, Prions, animal diseases, Cell Communication, Biology, cultured-cells, Prion Diseases, Mice, Neuroblastoma, Degenerative disease, neurotoxicity, Reaction Time, Tumor Cells, Cultured, medicine, Animals, CIDC - Divisie Bacteriologie en TSE's, Neurons, disease, Microglia, Interleukin-6, Tumor Necrosis Factor-alpha, Cell growth, Chemotaxis, General Neuroscience, Neurotoxicity, medicine.disease, Coculture Techniques, Peptide Fragments, In vitro, nervous system diseases, medicine.anatomical_structure, nervous system, scrapie prion proteins, Culture Media, Conditioned, Nerve Degeneration, Neuroglia, Neuron, Neuroscience, Interleukin-1 |
| الوصف: | Previous studies have demonstrated a role for microglia in the neuronal loss that occurs in the transmissible spongiform encephalopathies or prion diseases. In the present studies, the processes that lead to the death of neurones treated with synthetic peptides derived from the prion protein (PrP) were fully activated within 1 h, although neuronal cell death was not seen until 24 h later. Similarly, neurones exposed to PrP peptides for only 1 h activated microglia and a temporal relationship between the production of interleukin-6, an indicator of microglial activation, and microglial killing of PrP-treated neurones was also demonstrated. Activation of microglia and microglia-mediated killing of PrP-treated neurones or scrapie-infected neuroblastoma cells were maximal only when microglia were in direct contact with neurones. |
| وصف الملف: | application/octet-stream; text/html |
| اللغة: | English |
| تدمد: | 0959-4965 1695-1700 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fd3ea8c66858a797ca4be75a84a2c5Test https://doi.org/10.1097/00001756-200209160-00025Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....25fd3ea8c66858a797ca4be75a84a2c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09594965 16951700 |
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