Efficacy of pulsed dye laser treatment for common warts is not influenced by the causative HPV type: a prospective study
| العنوان: | Efficacy of pulsed dye laser treatment for common warts is not influenced by the causative HPV type: a prospective study |
|---|---|
| المؤلفون: | Yoseph Fichman, Emmilia Hodak, Moshe Lapidoth, Sigal Mazor, Orit Caplan, Shlomit Halachmi, Dana G. Wolf, Assi Levi |
| المصدر: | Lasers in Medical Science. 33:773-777 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Adolescent, Biopsy, Lasers, Dye, Dermatology, Logistic regression, Young Adult, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Statistical significance, Internal medicine, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Adverse effect, Prospective cohort study, Papillomaviridae, Common warts, Aged, Hpv types, business.industry, Middle Aged, medicine.disease, Response to treatment, Treatment Outcome, Female, Surgery, Warts, business, Verruca Vulgaris |
| الوصف: | Verruca vulgaris (VV) is a prevalent skin condition caused by various subtypes of human papilloma virus (HPV). The most common causes of non-genital lesions are HPV types 2 and 4, and to a lesser extent types 1, 3, 26, 29, and 57. Although numerous therapeutic modalities exist, none is universally effective or without adverse events (AE). Pulsed dye laser (PDL) is a favorable option due to its observed efficacy and relatively low AE rate. However, it is not known which verrucae are most likely to respond to PDL, or whether the causative viral subtype influences this response. The objective of this prospective blinded study was to assess whether the HPV subtype was predictive of response to PDL. For that matter, 26 verrucae from 26 immunocompetent patients were biopsied prior to treatment by PDL. HPV coding sequences were isolated and genotyped using PCR analysis. Patients were treated by PDL (595 nm wavelength, 5 mm spot size, 1.5 ms pulse duration, 12 J/cm2 fluence) once a month for up to 6 months, and clinical response was assessed. Binary logistic regression analysis and linear logistic regression analysis were used in order to evaluate statistical significance. Different types of HPV were identified in 22 of 26 tissue samples. Response to treatment did not correlate with HPV type, age, or gender. As no association between HPV type and response to PDL therapy could be established, it is therefore equally effective for all HPV types and remains a favorable treatment option for all VV. |
| تدمد: | 1435-604X 0268-8921 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d17428fed0c22e8cbc8b6f6bd74e7bTest https://doi.org/10.1007/s10103-017-2413-5Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....25d17428fed0c22e8cbc8b6f6bd74e7b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1435604X 02688921 |
|---|