Risk of minor and major fetal malformations in diabetics with high haemoglobin A1c values in early pregnancy
| العنوان: | Risk of minor and major fetal malformations in diabetics with high haemoglobin A1c values in early pregnancy |
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| المؤلفون: | T. Kesäniemi-Kuokkanen, P. Aula, Ulf-Håkan Stenman, Kari Teramo, K. Ylinen |
| المصدر: | BMJ. 289:345-346 |
| بيانات النشر: | BMJ, 1984. |
| سنة النشر: | 1984 |
| مصطلحات موضوعية: | Adult, Risk, medicine.medical_specialty, endocrine system diseases, Pregnancy in Diabetics, Early pregnancy factor, High haemoglobin, Congenital Abnormalities, Pregnancy, Diabetes mellitus, medicine, Humans, Risk factor, General Environmental Science, Gynecology, Glycated Hemoglobin, Fetus, biology, Obstetrics, business.industry, Incidence (epidemiology), General Engineering, Obstetrics and Gynecology, General Medicine, medicine.disease, % total haemoglobin, Diabetes Mellitus, Type 1, Insulin dependent diabetes, Metabolic control analysis, biology.protein, General Earth and Planetary Sciences, Gestation, Female, business, Research Article |
| الوصف: | Maternal haemoglobin A1c (HbA1c) values were measured before the end of the 15th week of gestation in 142 pregnancies in women with insulin dependent diabetes. In pregnancies complicated by fetal malformations (n = 17) the mean initial HbA1c value was 9.5 (SD 1.8)% of the total haemoglobin concentration, which was significantly (p less than 0.001) higher than in pregnancies without malformations (8.0 (SD 1.4)%; n = 125). HbA1c values did not differ between pregnancies complicated by minor and major fetal malformations, but the rate of malformations showed a positive relation to the HbA1c value in early pregnancy (chi 2 = 11.9; p = 0.001). Fetal malformations occurred in six out of 17 pregnancies (35.3%) in mothers whose initial HbA1c value was 10% or more, in eight out of 62 pregnancies (12.9%) in mothers with initial values between 8.0% and 9.9%, and in only three out of 63 pregnancies (4.8%) in mothers with an initial value below 8.0%. These data support the hypothesis that the increased incidence of fetal malformations in mothers with insulin dependent diabetes is associated with maternal hyperglycaemia during organogenesis. Hence diabetic women who are planning to have a child--especially those with a high HbA1c value--should receive intensified metabolic control. |
| تدمد: | 1468-5833 0959-8138 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cd8393e80c4b3e738ca28473b2290fTest https://doi.org/10.1136/bmj.289.6441.345Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....25cd8393e80c4b3e738ca28473b2290f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14685833 09598138 |
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