Development of a Predictive Monte Carlo Radiative Transfer Model for Ablative Fractional Skin Lasers
| العنوان: | Development of a Predictive Monte Carlo Radiative Transfer Model for Ablative Fractional Skin Lasers |
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| المؤلفون: | Ewan Eadie, Kenneth Wood, Kairui Feng, Chunhui Li, C. Tom A. Brown, Paul O'Mahoney, Sally H. Ibbotson, Kanheng Zheng, Lewis McMillan, Isla Rose Mary Barnard |
| المساهمون: | University of St Andrews. Centre for Biophotonics, University of St Andrews. School of Physics and Astronomy, University of St Andrews. Office of the Principal |
| المصدر: | Lasers in Surgery and Medicine. 53:731-740 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Materials science, Swine, medicine.medical_treatment, Monte Carlo method, Aesthetics, Dermatology, Ablation, Predictive, 01 natural sciences, law.invention, 010309 optics, 030207 dermatology & venereal diseases, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Atmospheric radiative transfer codes, Optical coherence tomography, law, 0103 physical sciences, Ablative case, medicine, Radiative transfer, Animals, Monte Carlo, QC, Skin, medicine.diagnostic_test, Lasers, DAS, Laser, QC Physics, Heat transfer, RC Internal medicine, Lasers, Gas, Surgery, Laser Therapy, Monte Carlo Method, Tomography, Optical Coherence, RC, Biomedical engineering |
| الوصف: | L.M. would like to acknowledge the funding from EPSRC grant code: EP/K503162/1. P.O'M. is funded by Medi‐Lase (registered charity SC 037390) and the Alfred Stewart Trust'. It is possible to enhance topical drug delivery by pretreatment of the skin with ablative fractional lasers (AFLs). However, the parameters to use for a given AFL to achieve the desired depth of ablation or the desired therapeutic or cosmetic outcome are hard to predict. This leaves open the real possibility of overapplication or underapplication of laser energy to the skin. In this study, we developed a numerical model consisting of a Monte Carlo radiative transfer (MCRT) code coupled to a heat transfer and tissue damage algorithm. The simulation is designed to predict the depth effects of AFL on the skin, verified with in vitro experiments in porcine skin via optical coherence tomography (OCT) imaging. Ex vivo porcine skin is irradiated with increasing energies (50–400 mJ/pixel) from a CO2 AFL. The depth of microscopic treatment zones is measured and compared with our numerical model. The data from the OCT images and MCRT model complement each other well. Nonablative thermal effects on surrounding tissue are also discussed. This model, therefore, provides an initial step toward a predictive determination of the effects of AFL on the skin. Publisher PDF |
| وصف الملف: | application/pdf |
| تدمد: | 1096-9101 0196-8092 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a43fbfb81a05efd407b628fcb066e6Test https://doi.org/10.1002/lsm.23335Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....25a43fbfb81a05efd407b628fcb066e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969101 01968092 |
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