Type 1 diabetes-related autoantibodies are rare in Alaska native populations
| العنوان: | Type 1 diabetes-related autoantibodies are rare in Alaska native populations |
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| المؤلفون: | Sven Ebbesson, Lisa K. Gilliam, Lynn M. Bekris, Åke Lernmark, Justin Mohatt |
| المصدر: | International Journal of Circumpolar Health; Vol 61, No 1 (2002) |
| بيانات النشر: | Informa UK Limited, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Health (social science), Epidemiology, Glutamate decarboxylase, Physiology, Type 2 diabetes, Impaired glucose tolerance, diabetes mellitus, latent autoimmune diabetes of the adult (LADA), glutamic acid decarboxylase (GAD), tyrosine phosphatase-like is- let antigen-2 (IA-2), autoantibodies, Eskimos, Diabetes mellitus, Internal medicine, medicine, Humans, Aged, Autoantibodies, Type 1 diabetes, Glutamate Decarboxylase, business.industry, Public Health, Environmental and Occupational Health, Autoantibody, Case-control study, General Medicine, Middle Aged, medicine.disease, Titer, Diabetes Mellitus, Type 1, Endocrinology, Inuit, Female, business, Alaska |
| الوصف: | Objectives. When clinical data were initially gathered from the Alaskan Eskimos in the 1950’s, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). Study design . Population based case control study Methods. We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). Results. Among subjects from one Inupiat village (#1) and one SiberianYup’ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal glucose tolerance (NGT). In village 1, GAD65 antibodies were not present in either diabetic subjects or those with IGT. One of the healthy controls (1%;1/97) was positive for GAD65Ab. Similarly, no subjects from this village with DM or IGT had positive IA-2Ab titers, and one healthy control (1%;1/97) was positive for IA-2Ab. In village 2, no DM subject was GAD65Ab positive. One (10%;1/10) of the IGT subjects and two (1.6%;2/129) of the healthy controls were positive for GAD65Ab. In this village, two of the DM subjects (12%;2/17), one of the IGT subjects (10%;1/10), and one of the healthy controls (0.8%;1/129) were IA-2Ab positive. No individual was positive for both GAD65Ab and IA-2Ab. Conclusion. Alaskan Inupiat and Siberian Yup’ik Eskimos appear to be predominantly affected by type 2 diabetes, not LADA. (Int J Circumpolar Health 2002; 61(1):21-31) Keywords: diabetes mellitus, latent autoimmune diabetes of the adult (LADA), glutamic acid decarboxylase (GAD), tyrosine phosphatase-like is- let antigen-2 (IA-2), autoantibodies, Eskimos |
| وصف الملف: | application/pdf |
| تدمد: | 1797-237X 1239-9736 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259eb85ea3553f093edc5b56ab96d2bdTest https://doi.org/10.3402/ijch.v61i1.17402Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....259eb85ea3553f093edc5b56ab96d2bd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1797237X 12399736 |
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