Prasugrel versus clopidogrel in stent-assisted coil embolization of unruptured intracranial aneurysms
| العنوان: | Prasugrel versus clopidogrel in stent-assisted coil embolization of unruptured intracranial aneurysms |
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| المؤلفون: | M. Lonjon, Marina Sachet, Jean Gaudart, Yves Chau, Jacques Sedat, Stephanie Beuil |
| المساهمون: | Unité de NeuroInterventionnelle, Hôpital Saint-Roch [Nice], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), unité de neurochirurgie, Hôpital Pasteur [Nice] (CHU), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Gaudart, Jean |
| المصدر: | Interventional Neuroradiology Interventional Neuroradiology, Edizioni del Centauro, 2016, ⟨10.1177/1591019916669090⟩ |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Acute coronary syndrome, Prasugrel, Ticlopidine, medicine.medical_treatment, stenting, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Occlusion, medicine, Humans, cardiovascular diseases, Coil embolization, Aged, Aspirin, business.industry, Stent, Intracranial Aneurysm, Middle Aged, Clopidogrel, medicine.disease, Combined Modality Therapy, Embolization, Therapeutic, Aneurysm, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Surgery, prasugrel, Clinical trial, Treatment Outcome, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, coiling, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Drug Therapy, Combination, Female, Stents, business, Prasugrel Hydrochloride, 030217 neurology & neurosurgery, Platelet Aggregation Inhibitors, medicine.drug |
| الوصف: | Background Thromboembolic complications are the main problem in stent-assisted coil embolization of unruptured intracranial aneurysms. The combination of aspirin and clopidogrel is generally used to decrease these complications, but some patients do not respond to clopidogrel and have a higher risk of stent thrombosis. In cardiology, clinical trials have shown that prasugrel reduced the incidence of ischaemic events in patients with acute coronary syndrome compared with clopidogrel but, according to several authors, prasugrel would produce an increased risk of cerebral haemorrhagic complications. Objective The purpose of this study was to determine whether prasugrel would be more effective than clopidogrel in reducing procedural events in patients with an unruptured aneurysm treated endovascularly with coils and stent. Materials and methods Two hundred consecutive patients with intracranial aneurysms were treated using coiling and stenting procedures. The first 100 patients were administered a dual antiplatelet of aspirin and clopidogrel, while the remaining 100 patients were administered a dual antiplatelet of aspirin and prasugrel. In each group data were collected on procedural and periprocedural haemorrhagic and ischaemic complications. Results Aneurysmal occlusion and haemorrhagic complications rates were identical in both groups. The number of thromboembolic events observed in the two groups of our study did not differ significantly, but the prasugrel group included more wide-neck aneurysms and more flow-diverted stents. Moreover, complications in the prasugrel group were more benign, explaining the significant difference in clinical outcomes between the two groups on Day 30. Conclusions Prasugrel reduces the clinical consequences of thromboembolic complications of endovascular treatment with stenting and coiling of unruptured intracranial aneurysms. |
| وصف الملف: | application/pdf |
| تدمد: | 2385-2011 1591-0199 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25897f1ac34e4c941fea5ec3c9aeb112Test https://pubmed.ncbi.nlm.nih.gov/27760885Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....25897f1ac34e4c941fea5ec3c9aeb112 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23852011 15910199 |
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