APC gene promoter methylation as a potential biomarker for lung cancer diagnosis: A meta-analysis
| العنوان: | APC gene promoter methylation as a potential biomarker for lung cancer diagnosis: A meta-analysis |
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| المؤلفون: | Fang Liu, Xiaoling Lu, He Huang, Xiaoxi Zhou |
| المصدر: | Thoracic Cancer Thoracic Cancer, Vol 12, Iss 21, Pp 2907-2913 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Genes, APC, Lung Neoplasms, Adenomatous polyposis coli, Population, Likelihood ratios in diagnostic testing, Internal medicine, medicine, Biomarkers, Tumor, Humans, Lung cancer, education, RC254-282, Early Detection of Cancer, education.field_of_study, promoter, biology, business.industry, adenomatous polyposis coli, Sputum, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, General Medicine, Original Articles, DNA Methylation, medicine.disease, lung cancer, meta‐analysis, Meta-analysis, Diagnostic odds ratio, biology.protein, Biomarker (medicine), Original Article, methylation, business, Bronchoalveolar Lavage Fluid, Lung cancer screening |
| الوصف: | Background The aim of this study was to quantitatively analysis the diagnostic performance of adenomatous polyposis coli (APC) gene promoter methylation in serum or sputum/bronchoalveolar lavage fluid (BLAF) as a biomarker for lung cancer identification through pooling of open published data. Methods The relevant electronic MEDLINE, EMBASE, Ovid, web of science and CNKI databases were systematically searched to identify the studies related to APC gene promoter methylation for lung cancer diagnosis. Data of true positive (tp), false positive (fp), false negative (fn) and true negative (tn) were extracted from the publications included in the study. The pooled diagnostic sensitivity, specificity and area under summary receiver operating characteristic (SROC) curve (AUC‐SROC) of APC gene promoter methylation were calculated. Publication bias was evaluated by Begg's funnel plot and Egger's line regression test. Results Fourteen studies associated with APC gene promoter methylation and lung cancer were identified in the databases and finally included in the meta‐analysis. The data was pooled using a random effect model due to significant statistical heterogeneity across the 14 studies (p The summary receiver operating characteristic (SROC) curve of APC gene promoter methylation for lung cancer diagnosis were 0.7 with the diagnostic sensitivity specificity of 0.43 (95% CI: 0.40–0.45) and 0.92 (95% CI: 0.90–0.95) respectively. |
| تدمد: | 1759-7714 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254e148216b31691fb082c2876e6fa2fTest https://pubmed.ncbi.nlm.nih.gov/34545707Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....254e148216b31691fb082c2876e6fa2f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17597714 |
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