CNB-001 reduces paraplegia in rabbits following spinal cord ischemia
| العنوان: | CNB-001 reduces paraplegia in rabbits following spinal cord ischemia |
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| المؤلفون: | Margot Knight, René Bombien, Mihaela Te Winkel, Paul D. Boitano, Ali Khoynezhad, Anja Muehle, Paul A. Lapchak, Daisy Chou |
| المصدر: | Neural Regeneration Research, Vol 14, Iss 12, Pp 2192-2198 (2019) Neural Regeneration Research |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, spinal cord ischemia, medicine.drug_class, Ischemia, Neuroprotection, lcsh:RC346-429, thoracic endovascular aortic repair, 03 medical and health sciences, 0302 clinical medicine, Bolus (medicine), Developmental Neuroscience, Neurotrophic factors, medicine, Spinal cord injury, curcumin analog, neurorepair, lcsh:Neurology. Diseases of the nervous system, business.industry, motor function, Memantine, medicine.disease, Receptor antagonist, spinal cord injury, 030104 developmental biology, Anesthesia, neuroprotection, Paraplegia, business, 030217 neurology & neurosurgery, thoraco-abdominal aortic aneurysm, medicine.drug, Research Article |
| الوصف: | Spinal cord ischemia associated with trauma and surgical procedures including thoraco-abdominal aortic aneurysm repair and thoracic endovascular aortic repair results in devastating clinical deficits in patients. Because spinal cord ischemia is inadequately treated, we studied the effects of [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol)] (CNB-001), a novel curcumin-based compound, in a rabbit SCI model. CNB-001 is known to inhibit human 5-lipoxygenase and 15-lipoxygenase and reduce the ischemia-induced inflammatory response. Moreover, CNB-001 can reduce the level of oxidative stress markers and potentiate brain-derived neurotrophic factor and brain-derived neurotrophic factor receptor signaling. The Tarlov scale and quantal analysis technique results revealed that CNB-001 administered as an intravenous dose (bolus) 30 minutes prior to spinal cord ischemia improved the behaviors of female New Zealand White rabbits. The improvements were similar to those produced by the uncompetitive N-methyl-D-aspartate receptor antagonist memantine. At 48 hours after aortic occlusion, there was a 42.7% increase (P < 0.05) in tolerated ischemia duration (n = 14) for rabbits treated with CNB-001 (n = 16), and a 72.3% increase for rabbits treated with the positive control memantine (P < 0.05) (n = 23) compared to vehicle-treated ischemic rabbits (n = 22). CNB-001 is a potential important novel treatment for spinal cord ischemia induced by aortic occlusion. All experiments were approved by the CSMC Institutional Animal Care and Use Committee (IACUC #4311) on November 1, 2012. |
| اللغة: | English |
| تدمد: | 1673-5374 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c622aaada39148486995b49b6449a6Test http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=12;spage=2192;epage=2198;aulast=LapchakTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24c622aaada39148486995b49b6449a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16735374 |
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