MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
| العنوان: | MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma |
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| المؤلفون: | XiangQi Meng, Ya Guo, Yanping Jian, Zexiang Deng, Hongwei Cai, YuanLiang Xue, Ning Liu |
| المصدر: | Bioengineered, Vol 0, Iss 0 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | endocrine system diseases, proliferation, Mice, Nude, Bone Neoplasms, Bioengineering, Biology, Applied Microbiology and Biotechnology, Transcription Factor 7-Like 2, Mice, Cell Movement, Cell Line, Tumor, osteosarcoma, T Cell Transcription Factor 1, medicine, Animals, Humans, Wnt Signaling Pathway, Transcription factor, microrna-22-3p, beta Catenin, Cell Proliferation, Gene knockdown, Wnt signaling pathway, General Medicine, medicine.disease, Gene Expression Regulation, Neoplastic, Transplantation, transcription factor 7-like 2, MicroRNAs, Catenin, Cancer research, Osteosarcoma, Transcription Factor 7-Like 2 Protein, TCF7L2, wnt/β-catenin, TP248.13-248.65, Biotechnology |
| الوصف: | Various studies have manifested that microRNAs (miRNAs) are involved in the modulation of the occurrence and development of osteosarcoma (OS). However, whether miR-22-3p is associated with OS growth remains unclear. In the study, the potential molecular mechanisms of miR-22-3p in OS was explored. It was affirmed that miR-22-3p was associated with distant metastasis and tumor size in OS patients, and reduced in OS tissues and cells while transcription factor 7-like 2 (TCF7L2) was elevated. Elevated miR-22-3p repressed OS cell progression, and the Wnt/β-catenin pathway, while elevated TCF7L2 was opposite. MiR-22-3p targeted TCF7L2 in OS. In functional rescue experiments, knockdown of miR-22-3p on OS progression and promotion of Wnt/β-catenin were reversed by simultaneous knockdown of TCF7L2. Transplantation experiments in nude mice showed that elevated miR-22-3p repressed OS tumor growth and decreased TCF7L2, Wnt and β-catenin. Shortly, this study suggest that miR-22-3p refrains the Wnt/β-catenin pathway by targeting TCF7L2 and thereby preventing OS deterioration. MiR-22-3p/TCF7L2 axis is supposed to be a candidate molecular target for future OS treatment. |
| اللغة: | English |
| تدمد: | 2165-5987 2165-5979 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240c67ab039509a85e0b9c64373e4b2cTest https://doaj.org/article/e637dfe03a4c40dc8538721a470a6000Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....240c67ab039509a85e0b9c64373e4b2c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21655987 21655979 |
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