Laser‐Assisted Hyaluronic Acid Delivery by Fractional Carbon Dioxide Laser in Facial Skin Remodeling: A Prospective Randomized Split‐Face Study in France
| العنوان: | Laser‐Assisted Hyaluronic Acid Delivery by Fractional Carbon Dioxide Laser in Facial Skin Remodeling: A Prospective Randomized Split‐Face Study in France |
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| المؤلفون: | Anne-Marie Collet-Villette, M. Benzaquen, Vanessa Pauly, J. Fongue |
| المصدر: | Lasers in Surgery and Medicine. 53:1166-1172 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Erythema, medicine.medical_treatment, Dentistry, Dermatology, 01 natural sciences, 010309 optics, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Edema, 0103 physical sciences, Hyaluronic acid, Ablative case, medicine, Humans, Prospective Studies, Hyaluronic Acid, Aged, Skin, integumentary system, business.industry, Carbon Dioxide, Middle Aged, Carbon dioxide laser, Laser assisted, Phototype, Facial skin, Treatment Outcome, chemistry, Lasers, Gas, Surgery, medicine.symptom, business |
| الوصف: | Background and objectives Combining the efficacy of ablative fractional carbon dioxide lasers (AFXL) to laser-assisted hyaluronic acid delivery (LAHAD) has not yet been studied. The objective of our study was to evaluate the safety and the efficacy of laser-assisted hyaluronic acid (HA) delivery with AFXL in facial skin remodeling. Study design/materials and methods We conducted a prospective, double-blinded, randomized split-face study on 20 patients from 30 to 70 years old, with a skin phototype from I to IV. Each patient received full-face treatment with AFXL, immediately followed by the application in droplets into the fractional ablative tunnels of 1 ml of HA gel on one hemiface and 1 ml of physiological saline on the other hemiface. To evaluate postlaser aftermath, the intensity of erythema, edema, and crusts was graded. To assess facial skin remodeling, we scored the improvement of skin texture, firmness, fine lines, and skin radiance from baseline. Patients were evaluated on the 3rd and 7th day, 1st and 3rd month using clinical evaluations, photographs, and patient questionnaires. Results We showed equivalence in postlaser aftermath between HA-treated and nontreated hemiface. Trend data analyses at the 3rd month suggested that immediate application of HA after AFXL resulted in a greater improvement in facial skin remodeling, especially for skin texture (mean score of 2.60 vs. 2.45) and skin firmness (mean score of 2.55 vs. 2.40). Skin radiance showed the best improvement, reaching almost a score of 5/10. Conclusions LAHAD with AFXL is a safe treatment showing promising results in facial skin remodeling. These findings need to be confirmed by a larger study to evaluate the value of LAHAD in daily clinical practice. Lasers Surg. Med. © 2021 Wiley Periodicals LLC. |
| تدمد: | 1096-9101 0196-8092 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2405d656f6dff799e3abbac60f07be4aTest https://doi.org/10.1002/lsm.23403Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2405d656f6dff799e3abbac60f07be4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969101 01968092 |
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