Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: a Mendelian randomization study
| العنوان: | Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: a Mendelian randomization study |
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| المؤلفون: | Resham L Gurung, Rajkumar Dorajoo, Yiamunaa M, Ling Wang, Sylvia Liu, Jian-Jun Liu, Yi Ming Shao, Yuqing Chen, Xueling Sim, Keven Ang, Tavintharan Subramaniam, Wern Ee Tang, Chee Fang Sum, Su Chi Lim |
| المصدر: | Clinical Kidney Journal |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, Mendelian randomization analysis, Renal function, Single-nucleotide polymorphism, Type 2 diabetes, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Mendelian randomization, medicine, telomere length, AcademicSubjects/MED00340, Transplantation, business.industry, Mendelian Randomization Analysis, Odds ratio, medicine.disease, Confidence interval, 030104 developmental biology, Nephrology, 030220 oncology & carcinogenesis, Original Article, type 2 diabetes, business, chronic kidney disease, Kidney disease |
| الوصف: | Background Chronic kidney disease (CKD) is common among people with type 2 diabetes (T2D), and increases the risk of kidney failure and cardiovascular diseases. Shorter leukocyte telomere length (LTL) is associated with CKD in patients with T2D. We previously reported single-nucleotide polymorphisms (SNPs) associated with LTL in an Asian population. In this study, we elucidated the association of these SNPs with CKD in patients with T2D using the Mendelian randomization (MR) approach. Methods The cross-sectional association of 16 LTL SNPs with CKD, defined as an estimated glomerular filtration rate of Results Genetically determined shorter LTL was associated with increased risk of CKD in patients with T2D (meta-IVW adjusted odds ratio = 1.51, 95% confidence interval 1.12–2.12, P = 0.007, Phet = 0.547). Similar results were obtained following sensitivity analysis. MR-Egger analysis (intercept) suggested no evidence of horizontal pleiotropy (β = 0.010, P = 0.751). Conclusions Our findings suggest that genetically determined LTL is associated with CKD in patients with T2D. Further studies are warranted to elucidate the causal role of telomere length in CKD progression. |
| اللغة: | English |
| تدمد: | 2048-8513 2048-8505 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a57833127eeb24342488a32df50627Test http://europepmc.org/articles/PMC8573005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....23a57833127eeb24342488a32df50627 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20488513 20488505 |
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