Blood Glucose Lowering Effect of Verapamil in Fasted Man
| العنوان: | Blood Glucose Lowering Effect of Verapamil in Fasted Man |
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| المؤلفون: | S. Röjdmark, D. E. H. Andersson |
| المصدر: | Hormone and Metabolic Research. 16:160-163 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Hepatic gluconeogenesis, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Biochemistry, Glucagon, Endocrinology, Internal medicine, medicine, Humans, Insulin, Glucose lowering, business.industry, Biochemistry (medical), Healthy subjects, Fasting, General Medicine, Verapamil, Basal (medicine), Female, business, Cytosolic calcium, medicine.drug |
| الوصف: | The current study was performed in order to investigate whether verapamil would affect the basal blood glucose concentration in a metabolic state characterized by an increased hepatic gluconeogenesis. For that purpose verapamil (5 mg/h) was infused i.v. during three hours in a group of healthy subjects fasted for 36 h, and for comparison also in healthy subjects fasted overnight. Verapamil was found to lower the basal blood glucose concentration in the 36 h fasted subjects. No effect of verapamil was seen in the overnight-fasted group. Since both the insulin and the glucagon concentrations remained unaffected by verapamil after the 36 h fast, other glucose-regulatory factors must have been responsible for the blood glucose lowering effect of the drug. An effect upon the cytosolic calcium concentration in the hepatocytes causing a decrease in the hepatic gluconeogenesis, is a feasible mechanism by which verapamil might have lowered the blood glucose concentration in the individuals subjected to a prolonged fast. |
| تدمد: | 1439-4286 0018-5043 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236bf82e8a666f4ca47cd32f85ba5b6bTest https://doi.org/10.1055/s-2007-1014923Test |
| رقم الانضمام: | edsair.doi.dedup.....236bf82e8a666f4ca47cd32f85ba5b6b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394286 00185043 |
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