Clinical Utility of Targeted Sequencing in Lung Cancer: Experience From an Autonomous Swedish Health Care Center
| العنوان: | Clinical Utility of Targeted Sequencing in Lung Cancer: Experience From an Autonomous Swedish Health Care Center |
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| المؤلفون: | Sofi Isaksson, Bassam Hazem, Håkan Griph, Gudrun N. Oskarsdottir, Per Levéen, Ronny Öhman, Johan Staaf, Anders Edsjö, Hans Brunnström, Jens Engleson, Karin Annersten, Karolina Holm, Kajsa Ericson Lindquist, Göran Jönsson, Mats Jönsson, Maria Planck, Frida Rosengren, Anna Karlsson, Christel Reuterswärd, Åke Borg |
| المصدر: | JTO Clinical and Research Reports JTO Clinical and Research Reports, Vol 1, Iss 1, Pp 100013-(2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, medicine.medical_treatment, Disease, medicine.disease_cause, lcsh:RC254-282, Exon, Internal medicine, medicine, Chemotherapy, Lung cancer, Lung, Massive parallel sequencing, business.industry, Never smoker, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, Mutation testing, Original Article, KRAS, Driver oncogenes, business |
| الوصف: | Objectives Mutation analysis by massive parallel sequencing (MPS) is routinely performed in the clinical management of lung cancer in Sweden. We describe the clinical and mutational profiles of lung cancer patients subjected to the first 1.5 years of treatment predictive MPS testing in an autonomous regional health care region. Methods Tumors from all patients with lung cancer who had an MPS test from January 2015 to June 2016 in the Skane health care region in Sweden (1.3 million citizens) were included. Six hundred eleven tumors from 599 patients were profiled using targeted sequencing with a 26-gene exon-focused panel. Data on disease patterns and characteristics of the patients subjected to testing were assembled, and correlations between mutational profiles and clinical features were analyzed. Results MPS with the 26-gene panel revealed alterations in 92% of the 611 lung tumors, with the most frequent mutations detected in the nontargetable genes TP53 (62%) and KRAS (37%). Neither KRAS nor TP53 mutations were associated with disease pattern, chemotherapy response, progression-free survival, or overall survival in advanced-stage disease treated with platinum-based doublet chemotherapy as a first-line treatment. Among targetable genes, EGFR driver mutations were detected in 10% of the tumors, and BRAF p.V600 variants in 2.3%. For the 71 never smokers (12%), targetable alterations (EGFR mutations, BRAF p.V600, MET exon 14 skipping, or ALK/ROS1 rearrangement) were detected in 59% of the tumors. Conclusion Although the increasing importance of MPS as a predictor of response to targeted therapies is indisputable, its role in prognostics or as a predictor of clinical course in nontargetable advanced stage lung cancer requires further investigation. |
| اللغة: | English |
| تدمد: | 2666-3643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232effa39270280f632e46dd1f19ad7eTest http://europepmc.org/articles/PMC8474272Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....232effa39270280f632e46dd1f19ad7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26663643 |
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