Efficacy and safety of dapagliflozin in Japanese patients with inadequately controlled type 1 diabetes (DEPICT‐5): 52‐week results from a randomized, open‐label, phase III clinical trial
| العنوان: | Efficacy and safety of dapagliflozin in Japanese patients with inadequately controlled type 1 diabetes (DEPICT‐5): 52‐week results from a randomized, open‐label, phase III clinical trial |
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| المؤلفون: | Hiroshi Ohashi, Eiichi Araki, Hirotaka Watada, Anna Maria Langkilde, Osamu Tomonaga, Yasuko Uchigata, Michiko Asano, Fredrik Thoren, Toshitaka Yajima, Hyosung Kim, Hitomi Fujii, Tadashi Okabe |
| المصدر: | Diabetes, Obesity & Metabolism |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Diabetic ketoacidosis, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Glucosides, Japan, Internal medicine, Internal Medicine, Clinical endpoint, Humans, Hypoglycemic Agents, Medicine, Benzhydryl Compounds, Dapagliflozin, Adverse effect, Type 1 diabetes, business.industry, Original Articles, medicine.disease, Clinical trial, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, chemistry, Tolerability, Original Article, business, Body mass index |
| الوصف: | Aims To investigate the safety and tolerability of 5 and 10 mg dapagliflozin added to insulin therapy over 52 weeks in Japanese patients with inadequately controlled type 1 diabetes mellitus (T1DM). Materials and methods This randomized, open‐label, parallel‐group, multicentre phase III clinical trial was conducted from October 26, 2015 to June 15, 2017. The primary endpoint was the occurrence of adverse events such as hypoglycaemia and diabetic ketoacidosis. Secondary endpoints included changes in glycaemic parameters, total daily insulin dosage and body weight over time. The efficacy of dapagliflozin in patients stratified by body mass index (BMI) |
| تدمد: | 1463-1326 1462-8902 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2310911b14b196e9e322bd4b599cd7a1Test https://doi.org/10.1111/dom.13922Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2310911b14b196e9e322bd4b599cd7a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14631326 14628902 |
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