Correlates of Prevalent and Incident Kaposi’s Sarcoma–Associated Herpesvirus Infection in Men Who Have Sex with Men
| العنوان: | Correlates of Prevalent and Incident Kaposi’s Sarcoma–Associated Herpesvirus Infection in Men Who Have Sex with Men |
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| المؤلفون: | Anna Wald, Corey Casper, Stephen R. Tabet, Connie Celum, John Pauk, Lawrence Corey |
| المصدر: | The Journal of Infectious Diseases. 185:990-993 |
| بيانات النشر: | Oxford University Press (OUP), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Herpesvirus 2, Human, viruses, Herpesvirus 1, Human, Antibodies, Viral, Men who have sex with men, Cohort Studies, Seroepidemiologic Studies, HIV Seronegativity, Surveys and Questionnaires, Internal medicine, Prevalence, Humans, Immunology and Allergy, Medicine, Homosexuality, Male, Seroconversion, Risk factor, business.industry, Incidence, Incidence (epidemiology), virus diseases, Hepatitis A, Herpes Simplex, Herpesviridae Infections, Sexually Transmitted Diseases, Viral, Odds ratio, Hepatitis B, medicine.disease, Sexual Partners, Infectious Diseases, Herpesvirus 8, Human, Immunology, Viral disease, business |
| الوصف: | Infection with Kaposi’s sarcoma– associated herpesvirus (KSHV) is common among men who have sex with men (MSM). To determine correlates of infection, 578 human immunodeficiency virus (HIV)– negative MSM were assessed by serologic assays, questionnaires, and physical examinations. At baseline, 76 (16%) of 474 participants were KSHV seropositive. Prevalent KSHV infection was significantly associated with hepatitis A (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.5– 7.5), hepatitis B seropositivity (OR, 2.6; 95% CI, 1.4–4 .8), herpes simplex virus (HSV)–2 (OR, 2.4; 95% CI, 1.3–4 .4), and . 4 male partners in the previous 6 months (OR, 1.9; 95% CI, 1.1–3 .2). Fifteen KSHV seroconversions (4%) were observed for an incidence of 3.8/ 100 person-years, similar to HSV-1 incidence in this cohort and more frequent than incidence of HIV and HSV-2. Reporting >1 HIV-positive partner (OR, 5.9; 95% CI, 1.8– 19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1–2 3.0), and lymphadenopathy in the past 6 months (OR, 7.7; 95% CI, 1.9–3 1.0) correlated with KSHV seroconversion. Since the identification of Kaposi’s sarcoma‐associated herpesvirus (KSHV), epidemiologic studies have attempted to identify risk factors associated with KSHV acquisition. In North America and Western Europe, men who have sex with men (MSM) have a prevalence of KSHV infection of 15%‐30% that is associated with a large number of sex partners and a history of sexually transmitted infections (STIs) [1]. However, findings in these investigations regarding specific sexual behaviors that may transmit KSHV are conflicting and have led to the lack of a consensus about modes of acquisition [2, 3]. Failure to definitively identify behaviors that may predispose to infection with KSHV is due to many factors, including a focus on prevalent KSHV infections and imperfect serologic tools. To determine risk factors associated with prevalent and incident KSHV infection and clinical symptoms associated with KSHV acquisition, we studied a cohort of 474 human immunodeficiency virus (HIV)‐negative men for KSHV infection by use of an indirect fluorescent antibody (IFA) test to define prevalent KSHV infection and EIA to confirm seroconversion. Detailed semiannual questionnaires about risk behaviors and clinical symptoms were used to determine risk factors associated with KSHV seroprevalence and seroincidence. |
| تدمد: | 1537-6613 0022-1899 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2244f02138d01f3bcfc8907d7488ba7cTest https://doi.org/10.1086/339605Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2244f02138d01f3bcfc8907d7488ba7c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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