Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study
| العنوان: | Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study |
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| المؤلفون: | Hao-Long Zeng, Dao-Yuan Yue, Wei Liu, Xu Wang, Huijun Li, Hao Li, Qing Yang, Leike Zhang, Qing-Bin Lu |
| المصدر: | Clinical Infectious Diseases Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Microbiology (medical), China, medicine.medical_specialty, fatal outcome, media_common.quotation_subject, Lymphocyte, medicine.medical_treatment, 030204 cardiovascular system & hematology, Procalcitonin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Lactate dehydrogenase, Major Article, medicine, Humans, 030212 general & internal medicine, Stage (cooking), Aged, Retrospective Studies, media_common, SARS-CoV-2, business.industry, Convalescence, COVID-19, Retrospective cohort study, Prognosis, AcademicSubjects/MED00290, Infectious Diseases, medicine.anatomical_structure, Cytokine, chemistry, Cohort, Laboratories, business |
| الوصف: | Background Patients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors for fatal outcome remain sparsely investigated. Methods A retrospective cohort study was performed in a cohort of patients with confirmed COVID-19 in one designated hospital in Wuhan, China, from 17 January–5 March 2020. The laboratory parameters and a panel of cytokines were consecutively evaluated until patients’ discharge or death. The laboratory features that could be used to predict fatal outcome were identified. Results Consecutively collected data on 55 laboratory parameters and cytokines from 642 patients with COVID-19 were profiled along the entire disease course, based on which 3 clinical stages (acute stage, days 1–9; critical stage, days 10–15; and convalescence stage, day 15 to observation end) were determined. Laboratory findings based on 75 deceased and 357 discharged patients revealed that, at the acute stage, fatality could be predicted by older age and abnormal lactate dehydrogenase (LDH), urea, lymphocyte count, and procalcitonin (PCT) level. At the critical stage, the fatal outcome could be predicted by age and abnormal PCT, LDH, cholinesterase, lymphocyte count, and monocyte percentage. Interleukin 6 (IL-6) was remarkably elevated, with fatal cases having a more robust production than discharged cases across the whole observation period. LDH, PCT, lymphocytes, and IL-6 were considered highly important prognostic factors for COVID-19–related death. Conclusions The identification of predictors that were routinely tested might allow early identification of patients at high risk of death for early aggressive intervention. A full description of the laboratory abnormalities for coronavirus disease 2019 (COVID-19) is reported, based on which 3 clinical stages of the disease were defined and their application in predicting fatal COVID-19 was explored. |
| تدمد: | 1537-6591 1058-4838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2163d2c2ae76a6d6b671b8a315c679f7Test https://doi.org/10.1093/cid/ciaa574Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2163d2c2ae76a6d6b671b8a315c679f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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