Clinical Relevance of Random Biopsies From the Esophagogastric Junction After Complete Eradication of Barrett's Esophagus is Low
| العنوان: | Clinical Relevance of Random Biopsies From the Esophagogastric Junction After Complete Eradication of Barrett's Esophagus is Low |
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| المؤلفون: | Charlotte N. Frederiks, Sanne N. van Munster, Esther A. Nieuwenhuis, Lorenza Alvarez Herrero, Alaa Alkhalaf, Boudewijn E. Schenk, Erik J. Schoon, Wouter L. Curvers, Arjun D. Koch, Pieter-Jan F. de Jonge, Thjon Tang, Wouter B. Nagengast, Jessie Westerhof, Martin H.M.G. Houben, Jacques J.G.H.M. Bergman, Roos E. Pouw, Bas L.A.M. Weusten |
| المساهمون: | Gastroenterology and hepatology, CCA - Cancer Treatment and quality of life, CCA - Imaging and biomarkers, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, CCA - Cancer Treatment and Quality of Life, Gastroenterology & Hepatology |
| المصدر: | Clinical Gastroenterology and Hepatology. W.B. Saunders Ltd Dutch Barrett Expert Centers 2023, ' Clinical Relevance of Random Biopsies From the Esophagogastric Junction After Complete Eradication of Barrett's Esophagus is Low ', Clinical Gastroenterology and Hepatology, vol. 21, no. 9, pp. 2260-2269.e9 . https://doi.org/10.1016/j.cgh.2022.11.012Test, https://doi.org/10.1016/j.cgh.2022.11.012Test Clinical gastroenterology and hepatology. W.B. Saunders Ltd Clinical Gastroenterology and Hepatology. W.B. Saunders |
| بيانات النشر: | W.B. Saunders, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Radiofrequency Ablation, Hepatology, Random Biopsies, Gastroenterology, Endoscopic Eradication Therapy, Barrett's Esophagus |
| الوصف: | Background & Aims: Although random histological sampling from the esophagogastric junction (EGJ) after complete eradication of Barrett's esophagus (BE) is recommended, its clinical relevance is questionable. This study aimed to assess the incidence and long-term outcomes of findings from random EGJ biopsies in a nationwide cohort with long-term follow-up. Methods: We included all patients with successful endoscopic eradication therapy (EET), defined as complete endoscopic eradication of all visible BE (CE-BE), for early BE neoplasia from the Dutch registry. Patients were treated and followed-up in 9 expert centers according to a joint protocol. Outcomes included the incidence of intestinal metaplasia (IM) at the EGJ (EGJ-IM) and the association between IM and visible (dysplastic) BE recurrence. Results: A total of 1154 patients were included with a median follow-up of 43 months (interquartile range, 22–69 months). At the time of CE-BE, persisting EGJ-IM was found in 7% of patients (78/1154), which was reproduced during further follow-up in 46% of patients (42/78). No significant association existed between persisting EGJ-IM at CE-BE and recurrent non-dysplastic or dysplastic BE (hazard ratio [HR], 1.15; 95% confidence interval [CI], 0.63–2.13 and HR, 0.73; 95% CI, 0.17-3.06, respectively). Among patients with no EGJ-IM at the time of CE-BE (1043/1154; 90%), EGJ-IM recurred in 7% (72/1043) after a median of 21 months (interquartile range, 15–36 months), and was reproduced during further follow-up in 26% of patients (19/72). No association was found between recurrent EGJ-IM and non-dysplastic or dysplastic recurrence (HR, 1.18; 95% CI, 0.67–2.06 and HR, 0.27; 95% CI, 0.04–1.96, respectively). Conclusion: Because EGJ-IM was not associated with a higher risk for recurrent disease, we recommend to consider abandoning random EGJ sampling after successful EET, under the condition that care is provided in expert centers, and the esophagus, including the EGJ, is carefully inspected (Netherlands Trial Register, NL7309). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1542-7714 1542-3565 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2093ba88f39c97a41f5b1d390c877aa7Test https://pure.eur.nl/en/publications/91225b39-af80-42fc-9636-7582059c16aeTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2093ba88f39c97a41f5b1d390c877aa7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15427714 15423565 |
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