Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China
| العنوان: | Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China |
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| المؤلفون: | Li-Li Sun, Lei Wang, Hong-Bo Ji, Sheng-Jie Yin, Xiao-Ying Wang, Di Shang, Le-Le Wang |
| المصدر: | Genet Test Mol Biomarkers |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, China, Esophageal Neoplasms, Retraction Notice, Single-nucleotide polymorphism, Biology, Adenocarcinoma, Polymorphism, Single Nucleotide, law.invention, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, law, Risk Factors, Stomach Neoplasms, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Allele, neoplasms, Gene, Genetics (clinical), Polymerase chain reaction, Alleles, Genetic Association Studies, Genetics, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Base Sequence, Haplotype, Case-control study, General Medicine, Middle Aged, digestive system diseases, Genotype frequency, 030104 developmental biology, Haplotypes, 030220 oncology & carcinogenesis, Case-Control Studies, Carcinoma, Squamous Cell, Female, PTPN1, Esophageal Squamous Cell Carcinoma |
| الوصف: | This case-control study investigated the association of single nucleotide polymorphisms in the PTPN1 gene with susceptibility to esophageal squamous cell carcinoma (ESCC) in Inner Mongolia, China.A total of 302 patients living in Inner Mongolia China who were pathologically diagnosed with ESCC between April 2012 and 2016 were selected for the ESCC group; 373 healthy individuals were selected for the control group. The rs2904268 CG, rs2230605 AG, and rs16995309 CT polymorphisms in the PTPN1 gene were detected by bidirectional polymerase chain reaction amplification of specific alleles. The haplotype frequencies were analyzed by SHEsis software. Binary logistic regression analysis was conducted to analyze risk factors associated with ESCC.Statistical differences between the ESCC and control groups were observed for history of smoking, drinking, and poor eating habits (all p 0.05). Both the rs2904268 CG CG and GG genotype frequencies were markedly higher in the ESCC group relative to the control group (both p 0.05). However, the genotype frequencies of rs2230605 AG and rs16995309 CT were similar between the ESCC and control groups (all p 0.05). Compared with the control group, the ESCC group had notably elevated frequencies of the GGC and GAT haplotypes and significantly reduced frequencies of CGC and GGT haplotypes (all p 0.05). A history of smoking, drinking, poor eating habits, the rs2904268 CG CG+GG genotypes, and the GAT haplotype were all identified as risk factors for ESCC (all p 0.05).These results indicated that the PTPN1 gene polymorphism rs2904268 is associated with susceptibility to ESCC in Inner Mongolia. |
| تدمد: | 1945-0257 1699-5309 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206c3839e5d9b454f5977363be5745e4Test https://pubmed.ncbi.nlm.nih.gov/34061658Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....206c3839e5d9b454f5977363be5745e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19450257 16995309 |
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