Design and synthesis of a ratiometric photoacoustic imaging probe activated by selenol for visual monitoring of pathological progression of autoimmune hepatitis†
| العنوان: | Design and synthesis of a ratiometric photoacoustic imaging probe activated by selenol for visual monitoring of pathological progression of autoimmune hepatitis† |
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| المؤلفون: | Qiufang Pang, Zhidong Qiu, Hong Liang, Liangliang Zhang, Zheng-Ming Yang, Chaobang Zhang, Shulin Zhao, Jiangke Qin |
| المصدر: | Chemical Science |
| بيانات النشر: | The Royal Society of Chemistry, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Selenocysteine, Selenol, Photoacoustic imaging in biomedicine, General Chemistry, Autoimmune hepatitis, medicine.disease, chemistry.chemical_compound, Chemistry, Nuclear magnetic resonance, chemistry, In vivo, Medical imaging, medicine, Ultrasound imaging, Visual monitoring |
| الوصف: | Photoacoustic (PA) imaging with both the high contrast of optical imaging and the high spatial resolution of ultrasound imaging has been regarded as a robust biomedical imaging technique. Autoimmune hepatitis (AIH) is the second largest liver inflammatory disease after viral hepatitis, but its pathogenesis is not fully understood probably due to the lack of an effective in vivo monitoring approach. In this work, an innovative selenol-activated ratiometric PA imaging probe APSel was developed for visual monitoring of pathological progress of AIH. Selenols including selenocysteine (Sec, the major form of Se-containing species in vivo) have been demonstrated to have an effective antioxidant role in inflammation. The reaction of APSel with selenol results in a blue shift of the PA spectrum peak from 860 nm to 690 nm, which enables the ratiometric PA imaging. The APSel probe displays high sensitivity and selectivity to Sec and other selenols. The APSel probe was then employed for ratiometric PA imaging of selenol in cells, and for monitoring the development of AIH in a murine model by tracking the changes of selenol level. The results revealed that the level of selenol was closely correlated with the development of AIH. The proposed APSel, as the first example of a selenol-responsive PA imaging probe, provides a new tool and approach to study and diagnose AIH diseases. A ratiometric photoacoustic imaging probe activated by selenol was developed for visual monitoring of pathological progression of autoimmune hepatitis. |
| اللغة: | English |
| تدمد: | 2041-6539 2041-6520 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200bf8d400125e5e9709bfb1be4e9ea6Test http://europepmc.org/articles/PMC8179563Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....200bf8d400125e5e9709bfb1be4e9ea6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20416539 20416520 |
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