Bladder preservation in urothelial carcinoma: current trends and future directions
| العنوان: | Bladder preservation in urothelial carcinoma: current trends and future directions |
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| المؤلفون: | Taylor Goodstein, Cheryl T Lee, Shang-Jui Wang |
| المصدر: | Current Opinion in Supportive & Palliative Care. 15:253-259 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Palliative care, medicine.medical_treatment, Urinary Bladder, MEDLINE, Cystectomy, Critical Care and Intensive Care Medicine, law.invention, Quality of life, Randomized controlled trial, law, medicine, Humans, Neoplasm Invasiveness, Radical surgery, Carcinoma, Transitional Cell, Oncology (nursing), business.industry, General surgery, Urinary diversion, Cancer, General Medicine, medicine.disease, Treatment Outcome, Urinary Bladder Neoplasms, Oncology, Quality of Life, business |
| الوصف: | Purpose of review To provide a contemporary rationale for bladder preservation as a treatment strategy for muscle-invasive urothelial carcinoma of the bladder. Although the standard of care for this important and serious clinical condition has been radical cystectomy augmented with neoadjuvant systemic chemotherapy, it is associated with substantial morbidity and quality of life (QoL) implications. This article explores the bladder sparing alternatives to radical cystectomy and urinary diversion to assist Urologists, Medical Oncologists, and Palliative Care providers in their informed decision making with patients. Recent findings Bladder sparing strategies such as partial cystectomy and trimodality therapy offer long-term cancer outcomes comparable to radical cystectomy in carefully selected patients. Moreover, the toxicity profile in patients, having improved over time, is acceptable, including a low risk of salvage cystectomy. Summary Bladder preservation therapy offers an alternative to radical cystectomy. In some patients, it can be done with curative intent and in others it can assist with symptom palliation. Bladder preservation can maintain QoL and provide similar oncologic outcomes to radical surgery, although randomized controlled trials have not been performed. Understanding patient selection is a critical step in balancing bladder preservation and cancer survival. |
| تدمد: | 1751-4266 1751-4258 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9c94eefd86e4730264ea3b21ff45f6Test https://doi.org/10.1097/spc.0000000000000579Test |
| رقم الانضمام: | edsair.doi.dedup.....1f9c94eefd86e4730264ea3b21ff45f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17514266 17514258 |
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