Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey
| العنوان: | Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey |
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| المؤلفون: | Seppo Koskinen, Marja Jylhä, Mika Kähönen, Juulia Jylhävä, M Hurme, Sari Stenholm, Laura Kananen, Tommi Härkänen, Olavi Ukkola, Terho Lehtimäki |
| المساهمون: | Tampere University, BioMediTech, Health Sciences, Department of Clinical Physiology and Nuclear Medicine, Clinical Medicine, Department of Clinical Chemistry |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Molecular biology, Population, lcsh:Medicine, Disease, Article, 03 medical and health sciences, Medical research, 0302 clinical medicine, Predictive Value of Tests, Cause of Death, Humans, Medicine, lcsh:Science, education, Aged, Cause of death, education.field_of_study, Multidisciplinary, Adiponectin, business.industry, lcsh:R, Hazard ratio, Age Factors, DNA, Middle Aged, Health Surveys, Circulating Cell-Free DNA, Confidence interval, 3. Good health, 3141 Health care science, 030104 developmental biology, Risk factors, Cardiovascular Diseases, Predictive value of tests, Female, lcsh:Q, 3111 Biomedicine, business, Biomarkers, 030217 neurology & neurosurgery, Demography |
| الوصف: | Increased levels of circulating cell-free DNA (cf-DNA) are associated with and predict poor health outcomes. However, its predictive ability for mortality in population-based samples remains understudied. We analysed the capability of cf-DNA to predict all-cause mortality and assessed whether it adds predictive value on top of the other risk factors in the Health 2000 survey (n = 1,257, 46–76 years of age, 15-years-follow-up, 18% deceased). When analysed in a multivariate model with the other factors that independently predicted mortality in the sample (age, gender, self-rated health, smoking and plasma levels of glucose and adiponectin), increases in cf-DNA levels were associated with increased risk of mortality (hazard ratio [HR] for 0.1 µg increase in cf-DNA: 1.017, 95% confidence interval [CI] 1.008–1.026, p = 0.0003). Inclusion of cf-DNA in the model improved the model fit and discrimination. Stratifying the analysis by cardiovascular disease (CVD) status indicated that cf-DNA predicted mortality equally well in individuals with (HR 1.018, 95% CI 1.008–1.026, p = 0.002) and without (HR 1.018, 95% CI 1.001–1.035, p = 0.033) CVD. In conclusion, our study indicates that cf-DNA level predicts mortality in middle-aged and older individuals, also among those with established CVD, and adds significant value to mortality prediction. Our results thus underscore the role of cf-DNA as a viable marker of health. |
| وصف الملف: | application/pdf; fulltext |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8ac8aa7229e4f3323105ad1ead7c2cTest https://doi.org/10.1038/s41598-020-70526-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1f8ac8aa7229e4f3323105ad1ead7c2c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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