Orally Administered IFN-α Acts Alone and in Synergistic Combination with Intraperitoneally Administered IFN-γ to Exert an Antitumor Effect Against B16 Melanoma in Mice
| العنوان: | Orally Administered IFN-α Acts Alone and in Synergistic Combination with Intraperitoneally Administered IFN-γ to Exert an Antitumor Effect Against B16 Melanoma in Mice |
|---|---|
| المؤلفون: | Tzu Y. Wu, Jyoti Masoor, Christina M. Fleischmann, W. Robert Fleischmann |
| المصدر: | Journal of Interferon & Cytokine Research. 18:17-20 |
| بيانات النشر: | Mary Ann Liebert Inc, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Antitumor activity, business.industry, Longevity, Immunology, Melanoma, Experimental, Administration, Oral, Interferon-alpha, Antineoplastic Agents, Drug Synergism, Cell Biology, Synergistic combination, Pharmacology, Mice, Inbred C57BL, Interferon-gamma, Mice, Virology, Animals, Medicine, Drug Therapy, Combination, Female, Nasal administration, business, neoplasms, Injections, Intraperitoneal, B16 melanoma |
| الوصف: | Administration of interferons (IFN) via the intranasal route recently has been shown to exert an antitumor activity against a variety of tumors in mice, including B16 melanoma inoculated intravenously. This study confirms the antitumor activity of orally administered IFN-alpha against B16 melanoma challenge using another route of tumor inoculation, the intraperitoneal route. It further demonstrates that orally administered IFN-alpha can synergistically interact with intraperitoneally administered IFN-gamma but not with intraperitoneally administered IFN-alpha. The results support the interpretation that the oral route may provide an effective alternative or supplement to current methods of IFN administration for the control of malignancies. |
| تدمد: | 1557-7465 1079-9907 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f831000d50c3e137afa74fd95d452a1Test https://doi.org/10.1089/jir.1998.18.17Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1f831000d50c3e137afa74fd95d452a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577465 10799907 |
|---|