Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria
| العنوان: | Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria |
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| المؤلفون: | M. H. Azor, Evandro A. Rivitti, Celina Wakisaka Maruta, C. A. de Brito, A. J. Da Silva Duarte, E. A. Futata, J C dos Santos, Maria Notomi Sato |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Oxford University Press (OUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Simvastatin, Translational Studies, Urticaria, T-Lymphocytes, medicine.medical_treatment, Suppressor of Cytokine Signaling Proteins, Adaptive Immunity, Superantigen, Immunology and Allergy, Medicine, Chemokine CCL3, Cell Cycle, Interleukin-17, Middle Aged, Interleukin-10, Cytokine, medicine.anatomical_structure, Female, lipids (amino acids, peptides, and proteins), Adult, Statin, medicine.drug_class, T cell, Immunology, INFLAMAÇÃO, Proinflammatory cytokine, Young Adult, Th2 Cells, Immune system, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Lovastatin, RNA, Messenger, Phytohemagglutinins, B cell, Aged, Cell Proliferation, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, nutritional and metabolic diseases, Th1 Cells, Immunity, Innate, Toll-Like Receptor 4, Suppressor of Cytokine Signaling 3 Protein, Chronic Disease, Leukocytes, Mononuclear, Cytokine secretion, business |
| الوصف: | Summary Immunological dysfunction has been described to occur in chronic idiopathic urticaria (CIU), most notably in association with an inflammatory process. Some pharmacological agents as statins – drugs used in hypercholesterolaemia – display a broad effect on the immune response and thus should be tested in vitro in CIU. Our main objectives were to evaluate the effects of statins on the innate and adaptive immune response in CIU. Simvastatin or lovastatin have markedly inhibited the peripheral blood mononuclear cells (PBMC) proliferative response induced by T and B cell mitogens, superantigen or recall antigen. Simvastatin arrested phytohaemaglutinin (PHA)-induced T cells at the G0/G1 phase, inhibiting T helper type 1 (Th1), Th2, interleukin (IL)-10 and IL-17A cytokine secretion in both patients and healthy control groups. Up-regulation of suppressor of cytokine signalling 3 (SOCS3) mRNA expression in PHA-stimulated PBMCs from CIU patients was not modified by simvastatin, in contrast to the enhancing effect in the control group. Statin exhibited a less efficient inhibition effect on cytokine production [IL-6 and macrophage inflammatory protein (MIP)-1α] induced by Toll-like receptor (TLR)-4, to which a statin preincubation step was required. Furthermore, statin did not affect the tumour necrosis factor (TNF)-α secretion by lipopolysaccharide (LPS)-stimulated PBMC or CD14+ cells in CIU patients. In addition, LPS-activated PBMC from CIU patients showed impaired indoleamine 2,3-dioxygenase (IDO) mRNA expression compared to healthy control, which remained at decreased levels with statin treatment. Statins exhibited a marked down-regulatory effect in T cell functions, but were not able to control TLR-4 activation in CIU patients. The unbalanced regulatory SOCS3 and IDO expressions in CIU may contribute to the pathogenesis of the disease. |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e888d6b9a5b6bcc70a7896846a23ad3Test https://doi.org/10.1111/j.1365-2249.2011.04473.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1e888d6b9a5b6bcc70a7896846a23ad3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652249 00099104 |
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