Effect of mirabegron, a novel β3-adrenoceptor agonist, on bladder function during storage phase in rats
| العنوان: | Effect of mirabegron, a novel β3-adrenoceptor agonist, on bladder function during storage phase in rats |
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| المؤلفون: | Seiji Kaku, Masashi Ukai, Toshiki Hatanaka, Akiyoshi Someya, Mai Watanabe, Shuichi Sato, Masanori Suzuki, Koji Ueshima, Akiyoshi Ohtake |
| المصدر: | Naunyn-Schmiedeberg's Archives of Pharmacology. 386:71-78 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Agonist, medicine.medical_specialty, Tolterodine Tartrate, medicine.drug_class, media_common.quotation_subject, Phenylpropanolamine, Urinary Bladder, Urology, Adrenergic beta-3 Receptor Agonists, Muscarinic Antagonists, urologic and male genital diseases, Urination, Cresols, Bladder outlet obstruction, medicine, Animals, Benzhydryl Compounds, Rats, Wistar, Oxybutynin, media_common, Pharmacology, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Cystometry, General Medicine, medicine.disease, Rats, Urinary Bladder Neck Obstruction, Thiazoles, Overactive bladder, Anesthesia, Mandelic Acids, Acetanilides, Female, Tolterodine, business, Mirabegron, medicine.drug |
| الوصف: | Mirabegron, a selective β(3)-adrenoceptor agonist, facilitates urine storage function by exerting a relaxing effect on bladder smooth muscle. Here, we investigated the effect of mirabegron on bladder function during the storage phase. We assessed the effect of mirabegron on the resting intravesical pressure in anesthetized rats and also tested antimuscarinics (oxybutynin and tolterodine) under the same experimental conditions. Mirabegron dose-dependently decreased the resting intravesical pressure, while oxybutynin and tolterodine showed no statistically significant effects on resting intravesical pressure. We also investigated the effect of mirabegron on bladder function using cystometry technique in conscious rats with bladder outlet obstruction. While mirabegron dose-dependently decreased the frequency of nonvoiding contractions, considered an index of abnormal response in bladder storage, no significant effects were noted on the amplitude of nonvoiding contractions, micturition pressure, threshold pressure, voided volume, residual volume, or bladder capacity. Neither oxybutynin nor tolterodine affected the frequency of nonvoiding contractions; however, oxybutynin increased residual volume and tended to decrease voided volume in a dose-dependent manner, and tolterodine dose-dependently decreased voided volume. Taken together, these results shed light on the suggestion of mirabegron as a therapeutic agent, compared with antimuscarinics, with its most prominent effect being the facilitation of bladder storage. |
| تدمد: | 1432-1912 0028-1298 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e337e1715a158d5387007894a88120eTest https://doi.org/10.1007/s00210-012-0814-3Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1e337e1715a158d5387007894a88120e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321912 00281298 |
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