Long-term high-physiological-dose growth hormone reduces intra-abdominal fat in HIV-infected patients with a neutral effect on glucose metabolism
| العنوان: | Long-term high-physiological-dose growth hormone reduces intra-abdominal fat in HIV-infected patients with a neutral effect on glucose metabolism |
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| المؤلفون: | S. B. Haugaard, Ole Kæseler Andersen, Birgitte Rønde Hansen, J E B Jensen, L Andresen, Johan Iversen, Frank Krieger Jensen |
| المصدر: | HIV Medicine. 11:266-275 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Intra-Abdominal Fat, Anti-HIV Agents, Injections, Subcutaneous, Adipose tissue, Blood lipids, HIV Infections, Carbohydrate metabolism, Placebo, Young Adult, Insulin resistance, Antiretroviral Therapy, Highly Active, Internal medicine, medicine, Body Fat Distribution, Humans, Pharmacology (medical), Triglycerides, Glucose tolerance test, Dose-Response Relationship, Drug, medicine.diagnostic_test, Human Growth Hormone, business.industry, HIV-Associated Lipodystrophy Syndrome, Health Policy, Glucose Tolerance Test, Middle Aged, medicine.disease, Arthralgia, Recombinant Proteins, Radiography, Cholesterol, Infectious Diseases, Endocrinology, Insulin Resistance, Lipodystrophy, business |
| الوصف: | Objectives The aim of the study was to investigate the effect of long-term high-physiological-dose recombinant human growth hormone (rhGH) therapy on fat distribution and glucose metabolism in HIV-infected patients. Methods Forty-six HIV-infected Caucasian men on highly active antiretroviral therapy (HAART), with an age range of 21–60 years and no significant comorbidity, were included in this randomized, placebo-controlled, double-blind, single-centre trial. Twenty-eight subjects were randomized to 0.7 mg/day rhGH, and 18 subjects to placebo, administered as daily subcutaneous injections between 1 and 3 pm for 40 weeks. Endpoints included changes in visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), limb fat mass, percentage of limb fat, plasma lipids, insulin resistance and glucose tolerance. Results VAT and trunk fat mass decreased significantly in the GH group compared with the placebo group [−19 cm2 (−11%) vs. 12 cm2 (6%), P=0.03, and −548 g (−9%) vs. 353 g (6%), P |
| تدمد: | 1468-1293 1464-2662 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e030a9b81a2feb8d641aadb4f2d944eTest https://doi.org/10.1111/j.1468-1293.2009.00775.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1e030a9b81a2feb8d641aadb4f2d944e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14681293 14642662 |
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