Exclusion of Int-6 from PML Nuclear Bodies by Binding to the HTLV-I Tax Oncoprotein
| العنوان: | Exclusion of Int-6 from PML Nuclear Bodies by Binding to the HTLV-I Tax Oncoprotein |
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| المؤلفون: | Pierre Jalinot, Raphaël Rousset, Christelle Desbois, Frédéric Bantignies |
| المصدر: | Science. 273:951-953 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Cytoplasm, Eukaryotic Initiation Factor-3, Recombinant Fusion Proteins, viruses, Promyelocytic Leukemia Protein, Biology, Transfection, Cell Line, Mice, Transactivation, Proto-Oncogene Proteins, Complementary DNA, medicine, Animals, Humans, Gene, Cellular localization, Cell Nucleus, Multidisciplinary, Oncogene, Tumor Suppressor Proteins, Nuclear Proteins, Gene Products, tax, medicine.disease, Virology, Neoplasm Proteins, Cell biology, Cell nucleus, Leukemia, medicine.anatomical_structure, HeLa Cells, Transcription Factors |
| الوصف: | The Tax transactivator of the human T cell leukemia virus type I (HTLV-I) exhibits oncogenic properties. A screen for proteins interacting with Tax yielded a complementary DNA (cDNA) encoding the human Int-6 protein. In mice, the Int-6 gene can be converted into a putative dominant negative oncogene after retroviral insertion. Here, Int-6 was localized in the cell nucleus to give a speckled staining pattern superposed to that of the promyelocytic leukemia (PML) protein. The binding of Tax to Int-6 caused its redistribution from the nuclear domains to the cytoplasm. Thus, Int-6 is a component of the PML nuclear bodies and Tax disrupts its normal cellular localization by binding to it. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d370e57e16d2ebfc252a5792ecf47c4Test https://doi.org/10.1126/science.273.5277.951Test |
| رقم الانضمام: | edsair.doi.dedup.....1d370e57e16d2ebfc252a5792ecf47c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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