T2–FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project
| العنوان: | T2–FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project |
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| المؤلفون: | Matija Snuderl, Sohil H. Patel, Brent Griffith, Yueren Zhou, Adam E. Flanders, Cheddhi Thomas, Rajan Jain, Daniel J. Brat, John G. Golfinos, Andrew S. Chi, Lee Cooper, Laila M. Poisson, Ana M. Franceschi |
| المصدر: | Clinical Cancer Research. 23:6078-6085 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Pathology, Imaging biomarker, Biology, Fluid-attenuated inversion recovery, Lesion, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Text mining, Internal medicine, Glioma, Image Processing, Computer-Assisted, medicine, Humans, Aged, Neoplasm Staging, Aged, 80 and over, Chromosome Aberrations, medicine.diagnostic_test, Brain Neoplasms, business.industry, Cancer, Magnetic resonance imaging, Middle Aged, Prognosis, medicine.disease, Magnetic Resonance Imaging, Chromosomes, Human, Pair 1, 030220 oncology & carcinogenesis, Female, Neoplasm Grading, medicine.symptom, business, Chromosomes, Human, Pair 19, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Purpose: Lower-grade gliomas (WHO grade II/III) have been classified into clinically relevant molecular subtypes based on IDH and 1p/19q mutation status. The purpose was to investigate whether T2/FLAIR MRI features could distinguish between lower-grade glioma molecular subtypes. Experimental Design: MRI scans from the TCGA/TCIA lower grade glioma database (n = 125) were evaluated by two independent neuroradiologists to assess (i) presence/absence of homogenous signal on T2WI; (ii) presence/absence of “T2–FLAIR mismatch” sign; (iii) sharp or indistinct lesion margins; and (iv) presence/absence of peritumoral edema. Metrics with moderate–substantial agreement underwent consensus review and were correlated with glioma molecular subtypes. Somatic mutation, DNA copy number, DNA methylation, gene expression, and protein array data from the TCGA lower-grade glioma database were analyzed for molecular–radiographic associations. A separate institutional cohort (n = 82) was analyzed to validate the T2–FLAIR mismatch sign. Results: Among TCGA/TCIA cases, interreader agreement was calculated for lesion homogeneity [κ = 0.234 (0.111–0.358)], T2–FLAIR mismatch sign [κ = 0.728 (0.538–0.918)], lesion margins [κ = 0.292 (0.135–0.449)], and peritumoral edema [κ = 0.173 (0.096–0.250)]. All 15 cases that were positive for the T2–FLAIR mismatch sign were IDH-mutant, 1p/19q non-codeleted tumors (P < 0.0001; PPV = 100%, NPV = 54%). Analysis of the validation cohort demonstrated substantial interreader agreement for the T2–FLAIR mismatch sign [κ = 0.747 (0.536–0.958)]; all 10 cases positive for the T2–FLAIR mismatch sign were IDH-mutant, 1p/19q non-codeleted tumors (P < 0.00001; PPV = 100%, NPV = 76%). Conclusions: Among lower-grade gliomas, T2–FLAIR mismatch sign represents a highly specific imaging biomarker for the IDH-mutant, 1p/19q non-codeleted molecular subtype. Clin Cancer Res; 23(20); 6078–85. ©2017 AACR. |
| تدمد: | 1557-3265 1078-0432 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4114746c0a4438458db4fa1fa403c0Test https://doi.org/10.1158/1078-0432.ccr-17-0560Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1c4114746c0a4438458db4fa1fa403c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573265 10780432 |
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