Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletion
| العنوان: | Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletion |
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| المؤلفون: | Martin J. Loessner, Mathias Schmelcher, Noël Stierlin, Léa V. Zinsli |
| المصدر: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021) Computational and Structural Biotechnology Journal, 19 |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | HAP, Homo-amino-acid polymer, NMR, Nuclear magnetic resonance, EPO, Erythropoietin, ANN, Artificial neural network, ELP, Elastin-like polypeptide, APC, Antigen-presenting cell, Review, SVM, Support vector machine, Ig, Immunoglobulin, Biochemistry, Epitope, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, BCR, B cell receptor, IL, Interleukin, PAMP, Pathogen-associated molecular pattern, LPS, Lipopolysaccharide, ADA, Anti-drug antibody, 0303 health sciences, Protein therapeutics, TCR, T cell receptor, Immunogenicity, Protein therapeutic, Anti-drug-antibody, T cell epitope, B cell epitope, GLK, Gelatin-like protein, PBMC, Peripheral blood mononuclear cell, RNN, Recurrent artificial neural network, ABR, Antigen-binding region, DC, Dendritic cell, Computer Science Applications, HLA, Human leukocyte antigen, PD, Pharmacodynamics, TAP, Transporter associated with antigen processing, PEG, Polyethylene glycol, 030220 oncology & carcinogenesis, TLR, Toll-like receptor, Biotechnology, PRR, Pattern recognition receptor, ER, Endoplasmatic reticulum, Glycosylation, Reductive methylation, Biophysics, HMM, Hidden Markov model, Mutagenesis (molecular biology technique), CDR, Complementarity determining region, Computational biology, Biology, PAS, Polypeptide composed of proline, alanine, and/or serine, PSA, Sialic acid polymers, 03 medical and health sciences, CRISPR, Clustered regularly interspaced short palindromic repeats, Genetics, PK, Pharmacokinetics, Deimmunization, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, MHC, Major histocompatibility complex, Bab, Binding antibody, XTEN, “Xtended” recombinant polypeptide, Nab, Neutralizing antibody, chemistry, PEGylation, TP248.13-248.65 |
| الوصف: | Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human medicine. An important challenge in the development of such therapeutics is their potential immunogenicity, which can induce production of anti-drug-antibodies, resulting in altered pharmacokinetics, reduced efficacy, and potentially severe anaphylactic or hypersensitivity reactions. For this reason, the development and application of effective deimmunization methods for protein drugs is of utmost importance. Deimmunization may be achieved by unspecific shielding approaches, which include PEGylation, fusion to polypeptides (e.g., XTEN or PAS), reductive methylation, glycosylation, and polysialylation. Alternatively, the identification of epitopes for T cells or B cells and their subsequent deletion through site-directed mutagenesis represent promising deimmunization strategies and can be accomplished through either experimental or computational approaches. This review highlights the most recent advances and current challenges in the deimmunization of protein therapeutics, with a special focus on computational epitope prediction and deletion tools. Computational and Structural Biotechnology Journal, 19 ISSN:2001-0370 |
| وصف الملف: | application/application/pdf |
| تدمد: | 2001-0370 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6eb34d6710e1da9ae4b3df006a799Test https://doi.org/10.1016/j.csbj.2020.12.024Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1bc6eb34d6710e1da9ae4b3df006a799 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20010370 |
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