Prospective nationwide multicentre cohort study of the clinical significance of autoimmune features in idiopathic interstitial pneumonias
| العنوان: | Prospective nationwide multicentre cohort study of the clinical significance of autoimmune features in idiopathic interstitial pneumonias |
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| المؤلفون: | Yoshikazu Inoue, Yasuhiko Yamano, Noriyoshi Ogawa, Shiro Imokawa, Yasuhiro Kondoh, Motoyasu Kato, Yoshio Taguchi, Masafumi Masuda, Noriyuki Enomoto, Hirofumi Chiba, Takafumi Suda, Kazutaka Mori, Hajime Takizawa, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Naoki Koshimizu, Yutaro Nakamura, Yusuke Kaida, Sakae Homma, Miho Kanai, Takehisa Sano, Hiroshi Mukae, Shinyu Izumi, Hiroyuki Matsuda, Naoki Hamada, Hironao Hozumi, Taisuke Akamatsu, Tomoyuki Fujisawa, Shigeo Muro, Takeshi Saraya, Koshi Yokomura, Naohiko Inase, Hiroshi Ishii, Shinobu Akagawa, Hironori Uruga |
| المصدر: | Thorax. 77:143-153 |
| بيانات النشر: | BMJ, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, Prognostic factor, Exacerbation, 03 medical and health sciences, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Internal medicine, medicine, Humans, Clinical significance, Idiopathic Interstitial Pneumonias, Prospective Studies, Idiopathic interstitial pneumonia, Retrospective Studies, 030203 arthritis & rheumatology, business.industry, Autoantibody, Retrospective cohort study, medicine.disease, 030228 respiratory system, Female, Lung Diseases, Interstitial, Tomography, X-Ray Computed, business, Cohort study |
| الوصف: | BackgroundSome patients with idiopathic interstitial pneumonia (IIP) show autoimmune features. Interstitial pneumonia with autoimmune features (IPAF) was recently proposed as a research concept in these patients. However, retrospective studies reported conflicting results of its prognosis. Therefore, this study was conducted to prospectively evaluate the clinical significance of autoimmune features in patients with IIP.MethodsThis nationwide multicentre study prospectively enrolled consecutive patients with IIP. At the diagnosis, we systematically evaluated 63 features suggestive of connective tissue diseases using a checklist including symptoms/signs and autoantibodies, which contained most items of the IPAF criteria and followed up with the patients. Clinical phenotypes were included in a cluster analysis.ResultsIn 376 patients with IIP enrolled, 70 patients (18.6%) met the IPAF criteria. The proportion of patients with IPAF was significantly lower in idiopathic pulmonary fibrosis (IPF) than in non-IPF (6.0% vs 24.3%, respectively). During a median observation period of 35 months, patients with IPAF more frequently developed systemic autoimmune diseases and had less frequent acute exacerbation of IIPs than patients with non-IPAF. IPAF diagnosis was significantly associated with better survival and was an independent positive prognostic factor in total and patients with non-IPF. Cluster analysis by similarity of clinical phenotypes identified a cluster in which there was a higher number of women, and patients had more autoimmune features and a better prognosis than other clusters.InterpretationThese observations suggest that some patients with IIP show autoimmune features with distinct characteristics and favourable prognosis. However, we were not able to determine the appropriate therapies for these patients. |
| تدمد: | 1468-3296 0040-6376 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba1ee46207209101521be6304ad017dTest https://doi.org/10.1136/thoraxjnl-2020-216263Test |
| رقم الانضمام: | edsair.doi.dedup.....1ba1ee46207209101521be6304ad017d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683296 00406376 |
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