Comparison of the Prognosis of Decompensated Cirrhosis in Patients with and Without Eradication of Hepatitis C Virus
| العنوان: | Comparison of the Prognosis of Decompensated Cirrhosis in Patients with and Without Eradication of Hepatitis C Virus |
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| المؤلفون: | Takashi Kumada, Satoshi Yasuda, Philip J. Johnson, Toshifumi Tada, Junko Tanaka, Kazuaki Chayama, William L. Irving, Hidenori Toyoda |
| المصدر: | INFECTIOUS DISEASES AND THERAPY |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, business.industry, Hepatitis C virus, Mortality rate, Inverse probability weighting, 030106 microbiology, medicine.disease_cause, Decompensated cirrhosis, Gastroenterology, Virus, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Internal medicine, Propensity score matching, medicine, Cumulative incidence, In patient, 030212 general & internal medicine, business |
| الوصف: | In patients with hepatitis C virus (HCV) infection and decompensated cirrhosis (DC), it is uncertain whether viral clearance is clinically meaningful and whether it decreases liver-related and non-liver-related mortality. The aim of this study was to assess whether viral eradication reduced liver-related and non-liver-related mortality in patients with HCV infection and DC. To clarify the impact of viral eradication on liver-related and non-liver-related mortality, 364 patients with DC who received direct-acting antivirals (DAAs) and achieved sustained virological response (SVR) in the UK (DAA group) were compared with 249 patients with DC who did not receive DAAs and who underwent symptomatic treatment in Japan (non-DAA group). Propensity score matching and inverse probability weighting (IPW) were performed to adjust the baseline characteristics in the DAA and non-DAA groups. Liver-related and non-liver-related mortality were analyzed using the competing risks IPW cumulative incidence functions estimator. The cumulative all-cause mortality rate in the DAA group was significantly lower than that in the non-DAA group (p |
| وصف الملف: | application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| تدمد: | 2193-6382 2193-8229 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b836f17214deef6c46d6e1f7aefc955Test https://doi.org/10.1007/s40121-021-00441-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b836f17214deef6c46d6e1f7aefc955 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21936382 21938229 |
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