The Role of Markers of Low-Grade Inflammation for the Early Time Course of Glycemic Control, Glucose Disappearance Rate, and β-Cell Function in Recently Diagnosed Type 1 and Type 2 Diabetes
| العنوان: | The Role of Markers of Low-Grade Inflammation for the Early Time Course of Glycemic Control, Glucose Disappearance Rate, and β-Cell Function in Recently Diagnosed Type 1 and Type 2 Diabetes |
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| المؤلفون: | Julia Szendroedi, Katharina S. Weber, Karsten Müssig, Christian Herder, Michael Roden, Bettina Nowotny, Klaus Strassburger, Giovanni Pacini |
| المصدر: | Diabetes Care. 38:1758-1767 |
| بيانات النشر: | American Diabetes Association, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Metabolic Clearance Rate, Endocrinology, Diabetes and Metabolism, Inflammation, Type 2 diabetes, Endothelial activation, Insulin resistance, Insulin-Secreting Cells, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Prediabetes, Glycemic, Glycated Hemoglobin, Advanced and Specialized Nursing, Type 1 diabetes, business.industry, Middle Aged, Intercellular Adhesion Molecule-1, medicine.disease, C-Reactive Protein, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 2, Female, medicine.symptom, E-Selectin, business, Biomarkers |
| الوصف: | OBJECTIVE Inflammatory processes are involved in the progression of insulin resistance and β-cell dysfunction in individuals with prediabetes and contribute to the development of diabetes. We hypothesized that higher levels of biomarkers of low-grade inflammation are associated with the early progression of recently diagnosed diabetes. RESEARCH DESIGN AND METHODS Within the prospective German Diabetes Study, patients with recently diagnosed type 1 (n = 42) and type 2 (n = 94) diabetes underwent detailed metabolic characterization within the first year after diagnosis and 2 years thereafter. Associations between changes in markers of low-grade inflammation with changes in glycemic control, β-cell function, and glucose disappearance rate were assessed using multivariable linear regression analysis. Associations were adjusted for age, sex, BMI, smoking status, and 2-year changes in BMI, smoking status, and glucose-lowering medication. RESULTS Patients with type 1 and type 2 diabetes exhibited good glucometabolic control at baseline (mean HbA1c 7.08 ± 1.58% [54 ± 17 mmol/mol] and 6.43 ± 0.98% [47 ± 11 mmol/mol], respectively) and 2 years thereafter (mean HbA1c 7.03 ± 1.20% [53 ± 13 mmol/mol] and 6.62 ± 1.14% [49 ± 13], respectively). Two-year increases of high-sensitivity C-reactive protein, soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 in type 2 diabetes and of IL-18 in type 1 diabetes were associated with 2-year increases of HbA1c. Additionally, 2-year increases of sE-selectin were associated with 2-year decreases of prehepatic β-cell function in type 2 diabetes (all P < 0.05). CONCLUSIONS These data indicate that with the clinical onset of diabetes, low-grade inflammation relates to worsening of glycemia and that endothelial activation may contribute to decreasing β-cell function. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5a1d3b995d86a3428a8630313aedb6Test https://doi.org/10.2337/dc15-0169Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b5a1d3b995d86a3428a8630313aedb6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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