Meningeal MAIT cells maintain meningeal and brain function
| العنوان: | Meningeal MAIT cells maintain meningeal and brain function |
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| المؤلفون: | Robyn Klein |
| المصدر: | Nat Immunol |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Mice, Oxidative Stress, Meninges, Cognition, Immunology, Animals, Brain, Immunology and Allergy, Article, Mucosal-Associated Invariant T Cells |
| الوصف: | Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain. However, the specific mechanisms by which immune cells promote normal neural function are not entirely understood. Mucosal-associated invariant T cells (MAIT cells) are a unique type of innate-like T cell with molecular and functional properties that remain to be better characterized. In the present study, we report that MAIT cells are present in the meninges and express high levels of antioxidant molecules. MAIT cell deficiency in mice results in the accumulation of reactive oxidative species in the meninges, leading to reduced expression of junctional protein and meningeal barrier leakage. The presence of MAIT cells restricts neuroinflammation in the brain and preserves learning and memory. Together, our work reveals a new functional role for MAIT cells in the meninges and suggests that meningeal immune cells can help maintain normal neural function by preserving meningeal barrier homeostasis and integrity. |
| تدمد: | 1529-2916 1529-2908 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2640ae1427c764db3078dd261c399fTest https://doi.org/10.1038/s41590-022-01368-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b2640ae1427c764db3078dd261c399f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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