Prenatal Exposure to Insecticides and Weight Trajectories Among South African Children in the VHEMBE Birth Cohort
| العنوان: | Prenatal Exposure to Insecticides and Weight Trajectories Among South African Children in the VHEMBE Birth Cohort |
|---|---|
| المؤلفون: | Joanne Kim, Seungmi Yang, Erica E. M. Moodie, Muvhulawa Obida, Riana Bornman, Brenda Eskenazi, Jonathan Chevrier |
| المصدر: | Epidemiology (Cambridge, Mass.), vol 33, iss 4 Epidemiology |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Insecticides, Epidemiology, Dichlorodiphenyl Dichloroethylene, Mosquito Vectors, Reproductive health and childbirth, Low Birth Weight and Health of the Newborn, Indoor residual spraying, Article, DDT, South Africa, Rare Diseases, Pregnancy, Preterm, Prenatal exposure, Anopheles, Pyrethrins, Infant Mortality, Animals, Humans, Birth Weight, 2.2 Factors relating to the physical environment, Conditions Affecting the Embryonic and Fetal Periods, Aetiology, Pediatric, Prevention, Child growth trajectory, Statistics, Infant, Perinatal Period - Conditions Originating in Perinatal Period, Malaria, Good Health and Well Being, Maternal Exposure, Prenatal Exposure Delayed Effects, Public Health and Health Services, Female, Body-Weight Trajectory, Birth Cohort |
| الوصف: | BackgroundDichlorodiphenyltrichloroethane (DDT) or pyrethroid insecticides are sprayed inside dwellings for malaria vector control, resulting in high exposure to millions of people, including pregnant women. These chemicals disrupt endocrine function and may affect child growth. To our knowledge, few studies have investigated the potential impact of prenatal exposure to DDT or pyrethroids on growth trajectories.MethodsWe investigated associations between gestational insecticide exposure and child growth trajectories in the Venda Health Examination of Mothers, Babies and their Environment, a birth cohort of 751 children born between 2012 and 2013 in South Africa. Based on child weight measured at follow-up and abstracted from medical records, we modeled weight trajectories from birth to 5 years using SuperImposition, Translation and Rotation, which estimated two child-specific parameters: size (average weight) and tempo (age at peak weight velocity). We estimated associations between peripartum maternal concentrations of serum DDT, dichlorodiphenyldichloroethylene, or urinary pyrethroid metabolites and SuperImposition, Translation and Rotation parameters using marginal structural models.ResultsWe observed that a 10-fold increase in maternal concentrations of the pyrethroid metabolite trans-3-(2,2,-dicholorvinyl)-2,2-dimethyl-cyclopropane carboxylic acid was associated with a 21g (95% confidence interval = -40, -1.6) smaller size among boys but found no association among girls (Pinteraction = 0.07). Estimates suggested that pyrethroids may be associated with earlier tempo but were imprecise. We observed no association with serum DDT or dichlorodiphenyldichloroethylene.ConclusionsInverse associations between pyrethroids and weight trajectory parameters among boys are consistent with hypothesized disruption of androgen pathways and with our previous research in this population, and support the endocrine-disrupting potential of pyrethroids in humans. |
| وصف الملف: | application/pdf |
| تدمد: | 1044-3983 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a45893246c2ad0958cab01a44785f2eTest https://doi.org/10.1097/ede.0000000000001487Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1a45893246c2ad0958cab01a44785f2e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10443983 |
|---|