Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients
| العنوان: | Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients |
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| المؤلفون: | Thomas Dörner, Nicolai Leuchten, Martin Aringer, B. Milke, B. Winkler-Rohlfing, S R Johnson, David I. Daikh |
| المصدر: | Lupus. 27:1431-1436 |
| بيانات النشر: | SAGE Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, myalgia, medicine.medical_specialty, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Germany, Surveys and Questionnaires, Internal medicine, Humans, Lupus Erythematosus, Systemic, Medicine, 030212 general & internal medicine, 030203 arthritis & rheumatology, Response rate (survey), business.industry, Autoantibody, Middle Aged, Ana Positive, medicine.disease, Cross-Sectional Studies, Joint pain, Female, Patient Participation, medicine.symptom, business, Rheumatism, Cohort study |
| الوصف: | Objective The European League Against Rheumatism and the American College of Rheumatology jointly embarked on a new classification criteria for systemic lupus erythematosus (SLE) project. Its first phase involved generation of a broad set of items potentially useful for classification of SLE. This study was undertaken to add the patient perspective to an expert Delphi approach and an early patient cohort study. Methods A national cross-sectional study was conducted. A self-report questionnaire was published in the “Schmetterling” (Butterfly), the quarterly journal of the German SLE patient association. Individuals with SLE were asked to anonymously complete the questionnaire, which asked for demographic details, organ manifestations, autoantibodies and symptoms. Results A total of 339 completed questionnaires out of 2498 were returned, a response rate of 13.6%; 83.2% reported they were ANA positive and 81.7% reported joint, 66.1% skin and 33.0% renal involvement. For the time before and in the first year after their SLE diagnosis, the majority reported fatigue (89.4%), joint pain (86.7%), photosensitivity (79.4%) and myalgia (76.1%). Of interest, more than half of the patients reported fever as an early symptom (53.7%). Conclusion For a Caucasian European SLE patient population, the overall characteristics suggest meaningful representation. While many symptoms were reported as expected, the high percentage of patients reporting fever and the significant number of patients with unexpected gastrointestinal complaints are of particular interest. These data add to the information on early SLE symptoms informing the development process of new SLE classification criteria. |
| تدمد: | 1477-0962 0961-2033 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19673544c80c9c23e37937947b8bec88Test https://doi.org/10.1177/0961203318776093Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....19673544c80c9c23e37937947b8bec88 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770962 09612033 |
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