Estrogen Receptors Alpha and Beta Mediate Synaptic Transmission in the PFC and Hippocampus of Mice
| العنوان: | Estrogen Receptors Alpha and Beta Mediate Synaptic Transmission in the PFC and Hippocampus of Mice |
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| المؤلفون: | Hannah Weiland, Michael Schöfbänker, Weiqi Zhang, Mingyue Zhang |
| المصدر: | International Journal of Molecular Sciences Volume 22 Issue 3 International Journal of Molecular Sciences, Vol 22, Iss 1485, p 1485 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Patch-Clamp Techniques, Hippocampus, Estrogen receptor, Synaptic Transmission, lcsh:Chemistry, Mice, chemistry.chemical_compound, 0302 clinical medicine, synapse, lcsh:QH301-705.5, Spectroscopy, ERα, Sex Characteristics, Estradiol, General Medicine, Computer Science Applications, Excitatory postsynaptic potential, 17ß-Estrdiol, Female, hormones, hormone substitutes, and hormone antagonists, Agonist, GABA Agents, medicine.drug_class, Diarylpropionitrile, sex difference, Prefrontal Cortex, Neurotransmission, Inhibitory postsynaptic potential, ERß, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Glutamatergic, Nitriles, medicine, Animals, Excitatory Amino Acid Agents, Physical and Theoretical Chemistry, Molecular Biology, Organic Chemistry, Estrogen Receptor alpha, Excitatory Postsynaptic Potentials, Mice, Inbred C57BL, Kinetics, 030104 developmental biology, Inhibitory Postsynaptic Potentials, lcsh:Biology (General), lcsh:QD1-999, chemistry, Propionates, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Distinct from ovarian estradiol, the steroid hormone 17ß-estradiol (E2) is produced in the brain and is involved in numerous functions, particularly acting as a neurosteroid. However, the physiological role of E2 and the mechanism of its effects are not well known. In hippocampal slices, 17ß-estradiol has been found to cause a modest increase in fast glutamatergic transmission because some of these effects are rapid and acute, they might be mediated by membrane-associated receptors via nongenomic action. Moreover, activation of membrane estrogen receptors can rapidly modulate neuron function in a sex-specific manner. To further investigate the neurological role of E2, we examined the effect of E2, as an estrogen receptor (ER) agonist, on synaptic transmission in slices of the prefrontal cortex (PFC) and hippocampus in both male and female mice. Whole-cell recordings of spontaneous excitatory postsynaptic currents (sEPSC) in the PFC showed that E2 acts as a neuromodulator in glutamatergic transmission in the PFC in both sexes, but often in a cell-specific manner. The sEPSC amplitude and/or frequency responded to E2 in three ways, namely by significantly increasing, decreasing or having no response. Additional experiments using an agonist selective for ERß, diarylpropionitrile (DPN) showed that in males the sEPSC and spontaneous inhibitory postsynaptic currents sIPSC responses were similar to their E2 responses, but in females the estrogen receptor ß (ERß) agonist DPN did not influence excitatory transmission in the PFC. In contrast, in the hippocampus of both sexes E2 potentiated the gluatmatergic synaptic transmission in a subset of hippocampal cells. These data indicate that activation of E2 targeting probably a estrogen subtypes or different downstream signaling affect synaptic transmission in the brain PFC and hippocampus between males versus females mice. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms22031485 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1947753a0f5003513f7b8aac9f7c916aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1947753a0f5003513f7b8aac9f7c916a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms22031485 |