Role of Amino Acid Transporter Expression as a Prognostic Marker in Patients With Surgically Resected Colorectal Cancer
| العنوان: | Role of Amino Acid Transporter Expression as a Prognostic Marker in Patients With Surgically Resected Colorectal Cancer |
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| المؤلفون: | Tetsunari Oyama, Chika Katayama, Takayuki Asao, Takahiro Takada, Yoko Motegi, Katsuya Osone, Ken Shirabe, Yoshikatsu Kanai, Takashi Yao, Kyoichi Kaira, Ryo Takahashi, Hiroomi Ogawa, Ryuji Katoh, Takehiko Yokobori, Hiroyuki Kuwano |
| المصدر: | Anticancer Research. 39:2535-2543 |
| بيانات النشر: | Anticancer Research USA Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Oncology, Cancer Research, medicine.medical_specialty, Fusion Regulatory Protein 1, Heavy Chain, Colorectal cancer, Cell, Large Neutral Amino Acid-Transporter 1, Metastasis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Antigen, Internal medicine, Molecular marker, Biomarkers, Tumor, medicine, Humans, Amino acid transporter, PI3K/AKT/mTOR pathway, Aged, business.industry, General Medicine, Middle Aged, Prognosis, medicine.disease, Gene Expression Regulation, Neoplastic, Ki-67 Antigen, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Colorectal Neoplasms, business |
| الوصف: | BACKGROUND/AIM L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers. However, the clinicopathological significance of LAT1 and 4F2 cell surface antigen (4F2hc) in patients with colorectal cancer (CRC) is unknown. The aim of this study was to clarify the prognostic significance of LAT1 expression in CRC patients who underwent surgical resection. MATERIALS AND METHODS Samples from one hundred and forty-seven patients were examined by immunohistochemistry. The expression of LAT1 and 4F2hc, and the Ki-67 labeling index were assessed using resected tumor specimens. RESULTS The positive expression of LAT1 and 4F2c was 80% (118/147) and 58% (86/147) (p |
| تدمد: | 1791-7530 0250-7005 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192fff467da68a276e37e417cc9facbfTest https://doi.org/10.21873/anticanres.13375Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....192fff467da68a276e37e417cc9facbf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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