Prognostic factors for overall survival in elderly patients with advanced ovarian cancer treated with chemotherapy: Results of a pooled analysis of three GINECO phase II trials
| العنوان: | Prognostic factors for overall survival in elderly patients with advanced ovarian cancer treated with chemotherapy: Results of a pooled analysis of three GINECO phase II trials |
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| المؤلفون: | Nicolas Gane, Eric Pujade-Lauraine, Gilles Freyer, Franck Chauvin, Claire Falandry, Fabien Tinquaut |
| المساهمون: | Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL) |
| المصدر: | Gynecologic Oncology Gynecologic Oncology, Elsevier, 2016, 143 (1), pp.22-6. ⟨10.1016/j.ygyno.2016.03.018⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Ovarian Neoplasms/*drug therapy/mortality, [SDV]Life Sciences [q-bio], Neutropenia, 03 medical and health sciences, chemistry.chemical_compound, Clinical Trials, Phase II as Topic, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, 80 and over, Humans, Clinical Trials, 030212 general & internal medicine, Hypoalbuminemia, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use, Prospective Studies, Stage (cooking), Prospective cohort study, Geriatric Assessment, Aged, Aged, 80 and over, Ovarian Neoplasms, Geriatrics, Chemotherapy, business.industry, Phase II as Topic, Obstetrics and Gynecology, General Medicine, medicine.disease, Prognosis, Carboplatin, 3. Good health, Surgery, Regimen, chemistry, 030220 oncology & carcinogenesis, Female, Ovarian cancer, business |
| الوصف: | International audience; BACKGROUND: The GINECO led three multicentric prospective phase II studies, Elderly Woman Ovarian Trials 1 (EWOT1), EWOT2, and EWOT3, to evaluate the impact of geriatric covariates on the outcome of elderly patients treated with six courses of first-line chemotherapy for FIGO stage IIIIV ovarian cancer. This pooled analysis was designed to evaluate the validity of the geriatric vulnerability parameters identified in EWOT3 (Falandry et al., 2013). PATIENTS AND METHODS: From 1997 to 2011, 266 patients were recruited: 83 in EWOT1, 72 in EWOT2, and 111 in EWOT3, which evaluated respectively a 4-weekly carboplatin-cyclophosphamide regimen, a 3-weekly standard carboplatin-paclitaxel doublet and a carboplatin monotherapy. All patients were analyzed in this pooled analysis for treatment completion, toxicity, and overall survival. RESULTS: The global treatment completion rate was 73% and ranged from 68% in EWOT2 to 74% in EWOT3. Toxicities were generally manageable: neutropenia was more frequent in EWOT2 and thrombopenia in EWOT1 and EWOT3. In multivariate analysis, covariates associated with decreased survival were: being "depressed" according to the investigators' assessment, hypoalbuminemia \textless35g/L, and FIGO stage IV. In addition, a Hospital Anxiety and Depression Scale (HADS) score\textgreater14 and Instrumental Activities of Daily Living (IADL) score\textless25 confirmed a deleterious impact in the EWOT2+EWOT3 population subanalysis. CONCLUSIONS: Despite moderate heterogeneity among the studies, this pooled analysis confirmed the deleterious effects on overall survival of emotional disorders ("depressed", as assessed by investigators or the HADS score), and decreased functionality (IADL score), in addition to FIGO stage. |
| اللغة: | English |
| تدمد: | 0090-8258 1095-6859 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a2479aa89f6eef8ee33694a4b83cecTest https://hal.archives-ouvertes.fr/hal-01850366Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....18a2479aa89f6eef8ee33694a4b83cec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00908258 10956859 |
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