Spontaneous splenic rupture in patient with metastatic melanoma treated with vemurafenib
| العنوان: | Spontaneous splenic rupture in patient with metastatic melanoma treated with vemurafenib |
|---|---|
| المؤلفون: | Francesco Barberini, Elisa Castellani, Carla Cini, Jacopo Desiderio, Giuseppe Noya, Roberto Cirocchi, Daniela Caracappa, Gloria Burini, Piero Covarelli, Antonio Rulli, Carlo Boselli |
| المصدر: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 10, Iss 1, p 155 (2012) |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Proto-Oncogene Proteins B-raf, chirurgia d'urgenza, Pathology, medicine.medical_specialty, Indoles, Metastatic melanoma, medicine.medical_treatment, Splenectomy, lcsh:Surgery, Case Report, lcsh:RC254-282, BRAF, Biological drugs, Surgical oncology, Medicine, Humans, In patient, Vemurafenib, Melanoma, Sulfonamides, Rupture, Spontaneous, business.industry, lcsh:RD1-811, Splenic Rupture, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Metastatic malignant melanoma, Oncology, Cancer research, Surgery, Spontaneous splenic rupture, business, medicine.drug |
| الوصف: | Background BRAF inhibitors such as vemurafenib are a new family of biological drugs, recently available to treat metastatic malignant melanoma. Methods We present the case of a 38-year-old man affected by metastatic melanoma who had been under treatment with vemurafenib for a few days. The patient suffered from sudden onset of abdominal pain due to intra-abdominal hemorrhage with profuse hemoperitoneum. An emergency abdominal sonography confirmed the clinical suspicion of a splenic rupture. Results The intraoperative finding was hemoperitoneum due to splenic two-step rupture and splenectomy was therefore performed. Histopathology confirmed splenic hematoma and capsule laceration, in the absence of metastasis. Conclusions This report describes the occurrence of a previously unreported adverse event in a patient with stage IV melanoma receiving vemurafenib. |
| تدمد: | 1477-7819 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1898f3d6a74b181cd54c80a2b46d7f92Test https://pubmed.ncbi.nlm.nih.gov/22846499Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1898f3d6a74b181cd54c80a2b46d7f92 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14777819 |
|---|