Antipyretic effect of ketoprofen
| العنوان: | Antipyretic effect of ketoprofen |
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| المؤلفون: | Mustafa Hacimustafaoglu, Denizmen Aygün, Solmaz Celebi, A. N. Citak Kurt, Emin Sami Arısoy, Y. Karali, M. Seringec, S. Akgoz |
| المساهمون: | Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı., Çelebi, Solmaz, Hacımustafaoğlu, Mustafa Kemal, Karalı, Yasin, Akgöz, Semra, Kurt, Ayşegül Neşe Çıtak |
| المصدر: | The Indian Journal of Pediatrics. 76:287-291 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Ketoprofen, Alternative medicine, Time Factors, Ibuprofen, Pediatrics, Compliance (physical), Body Temperature, law.invention, Randomized controlled trial, law, Child, Children, Anti-Inflammatory Agents, Non-Steroidal, Analgesics, Non-Narcotic, Nonsteroid Antiinflammatory Agent, Narcotic Analgesic Agent, Paracetamol, Treatment Outcome, Child, Preschool, Anesthesia, Female, Human, medicine.drug, Adolescent, Fever, Side effect, Vomiting, Analgesic, Groups by age, Emergency ward, Major clinical study, Blind, Article, Antipyretic activity, medicine, Health center, Humans, Pharmacokinetics, Antipyretic, Adverse effect, Acetaminophen, Analysis of Variance, Temperature measurement, Dose-Response Relationship, Drug, business.industry, Infant, Hospital admission, Drug efficacy, Tympanic thermometer, Taste disorder, Pediatrics, Perinatology and Child Health, Comparative study, business, Controlled study |
| الوصف: | Objective. To investigate the efficacy and side effect of ketoprofen as well as compliance with respect to the taste of the drug and compare these parameters with those of acetaminophen and ibuprofen. Methods. A total of 301 patients between 1-14 years of age who attended to emergency rooms of three medical centers with the complaint of fever that required antipyretic therapy were included in the study. Fever was measured with the aid of a tympanic thermometer (Braun Kronberg 6014) and followed for 4-6 hours. The measurement was repeated at 30, 60, 120 minutes, and again 4-6 hours after the initial assessment. Results. The mean age of the patients was 47.8 +/- 41.1 months. The patients randomly received 15 mg/kg/dose of acetaminophen (n=112 group 1), 0.5 mg/kg/dose of ketoprofen (n=105, group 2), or 10 mg/kg/dose of ibuprofen (n=84, group 3). Temperature records in three groups was 38.4 +/- 0.7 degrees C, 38.4 +/- 0.7 degrees C, and 38.5 +/- 0.5 degrees C at 30 minutes; 38.0 +/- 0.7 degrees C, 37.9 +/- 0.7 degrees C, and 38.0 +/- 0.6 degrees C at 60 minutes (p > 0.05), 37.7 +/- 0.6 degrees C, 37.6 +/- 0.7 degrees C, and 37.7 +/- 0.5 degrees C at 120 minutes (p > 0.05); 37.5 +/- 0.7 degrees C, 37.3 +/- 0.6 degrees C, and 37.4 +/- 0.6 degrees C at 4-6 hours after admission (P > 0.05) respectively. The fever was significantly lower at 30, 60, and 120 minutes in all groups (p < 0.05) respectively. Early vomiting after medication (< 6 hours) was observed in 3.8%, 13.5%, and 9.6% respectively whereas late vomiting (6-48 hours) occurred in 1.3%, 2.7%, and 5.8% respectively (p > 0.05). Bad taste was expressed by 5.1%, 12.2%, and 5.8% early (< 6 hours), and 3.9%, 8.1%, and 3.8% late (6-48 hours) (p > 0.05). There were no differences between age groups for antipyretic effect, taste and adverse effect in three drugs (p > 0.05). Conclusion. All three drugs were similar in terms of efficacy, adverse effects, and compliance within 48 hours of therapy. These results suggest that ketoprofen may be used for antipyresis as an alternative to acetaminophen and ibuprofen. |
| تدمد: | 0973-7693 0019-5456 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185a1d0adcf58bfacf37543aacd7da92Test https://doi.org/10.1007/s12098-008-0234-zTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....185a1d0adcf58bfacf37543aacd7da92 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09737693 00195456 |
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