MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
| العنوان: | MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes |
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| المؤلفون: | Marta Kazimierska, Jerzy Nowak, Piotr Fichna, Marta Fichna, Grzegorz K. Przybylski, Marek Ruchała, Magdalena Zurawek, Agnieszka Dzikiewicz-Krawczyk |
| المصدر: | Archivum Immunologiae et Therapiae Experimentalis |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cell signaling, Genotype, Addison’s disease, Short Communication, DNA Mutational Analysis, Immunology, Locus (genetics), Disease, Biology, medicine.disease_cause, Polymorphism, Single Nucleotide, Autoimmunity, 03 medical and health sciences, Addison Disease, Gene Frequency, Risk Factors, medicine, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Allele, Gene, Genotyping, Adaptor Proteins, Signal Transducing, Genetics, Variants, General Medicine, Middle Aged, MAVS, 3. Good health, Diabetes Mellitus, Type 1, Type 1 diabetes, 030104 developmental biology, Female, Poland |
| الوصف: | Mitochondrial antiviral signaling (MAVS) protein is an intracellular adaptor molecule, downstream of viral sensors, retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs). Impaired antiviral cell signaling might contribute to autoimmunity. Studies have recently shown variations in genes encoding RLRs as risk factors for autoimmune diseases. We investigated whether MAVS coding polymorphisms are associated with Addison’s disease (AD) and type 1 diabetes (T1D) in Polish population. We genotyped 140 AD, 532 T1D patients and 600 healthy controls for MAVS rs17857295, rs7262903, rs45437096 and rs7269320. Genotyping was performed by TaqMan assays. Distribution of the MAVS genotypes and alleles did not reveal significant differences between patients and controls (p > 0.05). This analysis did not indicate the association of the MAVS locus with susceptibility to AD and T1D. |
| تدمد: | 1661-4917 0004-069X 1785-7295 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181d25f10233d61fed84ebc14a294b21Test https://doi.org/10.1007/s00005-016-0426-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....181d25f10233d61fed84ebc14a294b21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16614917 0004069X 17857295 |
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