Evidence of a Functional B-Cell Immunodeficiency in Adults Who Experience Serogroup C Meningococcal Disease
| العنوان: | Evidence of a Functional B-Cell Immunodeficiency in Adults Who Experience Serogroup C Meningococcal Disease |
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| المؤلفون: | Robert C. Read, Andrew W. Heath, M.W. McKendrick, Ray Borrow, Jennifer Carlring, Rachel A. Foster, Andrew Lees |
| المصدر: | Clinical and Vaccine Immunology. 16:692-698 |
| بيانات النشر: | American Society for Microbiology, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Microbiology (medical), Adolescent, T-Lymphocytes, Clinical Biochemistry, Immunology, Stimulation, Meningitis, Meningococcal, Lymphocyte Activation, Meningococcal disease, Young Adult, Immune system, Antigen, medicine, Humans, Immunology and Allergy, B cell, Immunodeficiency, Cell Proliferation, B-Lymphocytes, biology, Immunologic Deficiency Syndromes, Bacterial polysaccharide, medicine.disease, medicine.anatomical_structure, Polyclonal antibodies, biology.protein, Female, Microbial Immunology |
| الوصف: | After adolescence, the incidence of meningococcal disease decreases with age as a result of the cumulative immunizing effect of repeated nasopharyngeal colonization. Nevertheless, some adults succumb to meningococcal disease, so we hypothesized that this is due to a subtle functional immunological defect. Peripheral blood lymphocytes derived from survivors of serogroup C meningococcal disease and from age- and sex-matched controls were incubated with a polyclonal B-cell activator containing anti-immunoglobulin D (α-δ-dex) employed to mimic antigen-specific stimuli encountered during immune responses to bacterial polysaccharides, with and without T-cell activation (using anti-CD3/anti-CD28). Subsequent proliferation and activation of T and B lymphocytes were measured. In patients, T-cell responses to polyclonal stimuli and the delivery of T-cell help to B cells were unimpaired. Levels of B-cell proliferation in response to α-δ-dex stimulation alone were low in all samples but were significantly lower in patients than in controls, and these differences were more pronounced with the addition of T-cell help. The data are consistent with the presence of a subtle immunodeficiency in adults who have exhibited susceptibility to meningococcal disease. This defect is manifested as an impaired B-cell response to T-cell-independent type 2 antigens analogous to bacterial capsular polysaccharide. |
| تدمد: | 1556-679X 1556-6811 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d34bbf1a506aaf9a55d28980a2cd80Test https://doi.org/10.1128/cvi.00485-08Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....17d34bbf1a506aaf9a55d28980a2cd80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1556679X 15566811 |
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