Syntheses of 1 H ‐Indoles, Quinolines, and 6‐Membered Aromatic N ‐Heterocycle‐Fused Scaffolds via Palladium(II)‐Catalyzed Aerobic Dehydrogenation under Alkoxide‐Free Conditions
| العنوان: | Syntheses of 1 H ‐Indoles, Quinolines, and 6‐Membered Aromatic N ‐Heterocycle‐Fused Scaffolds via Palladium(II)‐Catalyzed Aerobic Dehydrogenation under Alkoxide‐Free Conditions |
|---|---|
| المؤلفون: | Yo Sep Yang, Soo Lim Kim, Hyung Seok Yoo, Jeong Won Shin, Yoon Hu Jang, Seung Hwan Son, Nam-Jung Kim |
| المصدر: | Chemistry – An Asian Journal. 16:3469-3475 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Indole test, Organic Chemistry, Halogenation, chemistry.chemical_element, General Chemistry, Biochemistry, Catalysis, chemistry.chemical_compound, chemistry, Yield (chemistry), Halogen, Alkoxide, Organic chemistry, Dehydrogenation, Palladium |
| الوصف: | Aromatic N -heterocycle fused scaffolds such as indoles and quinolines are important core structures found in various bioactive natural products and synthetic compounds. Recently, various dehydrogenation methods with the help of alkoxides, known to significantly promote dihydro- or tetrahydro-heterocycles to be oxidized, were developed for the heterocycle synthesis. However, these approaches are sometimes unsuitable due to resulting undesired side reactions such as reductive dehalogenation. Herein, expedient syntheses of 1 H -indoles, quinolines, and 6-membered N -heterocycle-fused scaffolds from their hydrogenated forms through palladium(II)-catalyzed aerobic dehydrogenation under alkoxide-free conditions are reported. A total of 48 compounds were successfully synthesized with a wide range of functional groups including halogens (up to 99% yield). These methodologies provide facile routes for various privileged structures possessing aromatic N -heterocycles without the help of alkoxides, in highly efficient manners. |
| تدمد: | 1861-471X 1861-4728 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17700c40584fe9d15af4c57e6fc42aadTest https://doi.org/10.1002/asia.202100861Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....17700c40584fe9d15af4c57e6fc42aad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1861471X 18614728 |
|---|