Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules
| العنوان: | Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules |
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| المؤلفون: | Samantha L. Hodges, Alexandra A. Bouza, Lori L. Isom |
| المصدر: | Pharmacological Reviews. 74:1030-1050 |
| بيانات النشر: | American Society for Pharmacology & Experimental Therapeutics (ASPET), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, Potassium Channels, Voltage-Gated, Proteolysis, Sodium, Potassium, Humans, Membrane Proteins, Molecular Medicine, Calcium Channels, Peptides, Cell Adhesion Molecules, Ion Channels, Peptide Hydrolases |
| الوصف: | Several integral membrane proteins undergo regulated intramembrane proteolysis (RIP), a tightly controlled process through which cells transmit information across and between intracellular compartments. RIP generates biologically active peptides by a series of proteolytic cleavage events carried out by two primary groups of enzymes: sheddases and intramembrane-cleaving proteases (iCLiPs). Following RIP, fragments of both pore-forming and non-pore-forming ion channel subunits, as well as immunoglobulin super family (IgSF) members, have been shown to translocate to the nucleus to function in transcriptional regulation. As an example, the voltage-gated sodium channel |
| تدمد: | 1521-0081 0031-6997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170ada2a71eeab3140644dbf50229f21Test https://doi.org/10.1124/pharmrev.121.000340Test |
| رقم الانضمام: | edsair.doi.dedup.....170ada2a71eeab3140644dbf50229f21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15210081 00316997 |
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