أعرض في EDS

Evaluation of carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease

التفاصيل البيبلوغرافية
العنوان: Evaluation of carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease
المؤلفون: Renata Lopes, Maria Cristina de Andrade, Ana Lucia Cardoso Santos Abreu, Ana Paula Brecheret, Mauro Batista de Morais, Fernanda Luisa Ceragioli Oliveira
المصدر: Jornal de Pediatria v.95 n.6 2019
Jornal de Pediatria
Sociedade Brasileira de Pediatria (SBP)
instacron:SBPE
Jornal de Pediatria (Versão em Português), Vol 95, Iss 6, Pp 696-704 (2019)
Jornal de Pediatria, Vol 95, Iss 6, Pp 696-704 (2019)
Jornal de Pediatria, Volume: 95, Issue: 6, Pages: 696-704, Published: 25 NOV 2019
بيانات النشر: Elsevier BV, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, medicine.medical_specialty, Waist, Adolescent, Crianças, medicine.medical_treatment, Blood Pressure, Adolescents, Carotid Intima-Media Thickness, Gastroenterology, chemistry.chemical_compound, Risk Factors, Chronic kidney disease, Internal medicine, Humans, Medicine, Outpatient clinic, Sexual Maturation, cardiovascular diseases, Renal Insufficiency, Chronic, Carotid intima-media thickness, Child, Adolescentes, Children, Dialysis, Espessura intima-média carotídea, Doenças cardiovasculares, Creatinine, business.industry, Puberty, lcsh:RJ1-570, lcsh:Pediatrics, medicine.disease, Carotid Arteries, Cross-Sectional Studies, Cardiovascular diseases, Blood pressure, chemistry, Intima-media thickness, Cardiovascular Diseases, Hypertension, Pediatrics, Perinatology and Child Health, cardiovascular system, Insuficiência renal crônica, Female, business, Body mass index, Kidney disease
الوصف: Objective: To assess the carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease. Material and methods: Observational, cross-sectional study carried out at the Universidade Federal de São Paulo (chronic kidney disease outpatient clinics) with 55 patients (60% males) with a median age of 11.9 years (I25–I75: 9.2–14.8 years). Of the 55 patients, 43 were on conservative treatment and 12 were on dialysis. Serum laboratory parameters (creatinine, uric acid, C-reactive protein, total cholesterol and fractions, and triglycerides), nutritional status (z-score of body mass index, z-score of height/age), body fat (fat percentage and waist circumference), and blood pressure levels were evaluated. The carotid intima-media thickness measure was evaluated by a single ultrasonographer and compared with percentiles established according to gender and height. Data collection was performed between May 2015 and March 2016. Results: Of the children and adolescents with chronic kidney disease, 74.5% (95% CI: 61.0; 85.3) showed an increase (>P95) in carotid intima-media thickness. In patients with stages I and II hypertension, 90.9% had increased carotid intima-media thickness. Nutritional status, body fat and laboratory tests were not associated with increased carotid intima-media thickness. After multivariate adjustment, only puberty (PR = 1.30, p = 0.037) and stages I and II arterial hypertension (PR = 1.42, p = 0.011) were independently associated with carotid intima-media thickness alterations. Conclusion: The prevalence of increased carotid thickness was high in children and adolescents with chronic kidney disease. Puberty and arterial hypertension were independently associated with increased carotid intima-media thickness. Resumo: Objetivo: Avaliar a espessura médio-intimal da carótida e os fatores associados à doença cardiovascular em crianças e adolescentes com doença renal crônica. Material e métodos: Estudo observacional transversal feito na Universidade Federal de São Paulo (ambulatórios de doença renal crônica) com 55 pacientes (60% do sexo masculino) com mediana de 11,9 anos (I25-I75: 9,2–14,8). Dos 55 pacientes, 43 estavam em tratamento conservador e 12 em terapia dialítica. Foram avaliados os parâmetros laboratoriais séricos (creatinina, ácido úrico, proteína C-reativa, colesterol total e frações e triglicérides), estado nutricional (escore z de índice de massa corpórea, escore z de estatura/idade), gordura corporal (percentual de gordura e circunferência abdominal) e pressão arterial. A medida da espessura médio-intimal da carótida foi avaliada por um único ultrassonografista e comparada com percentis estabelecidos de acordo com o sexo e a estatura. A coleta de dados foi feita entre maio de 2015 e março de 2016. Resultados: Das crianças e adolescentes com doença renal crônica, 74,5% (IC 95%: 61,0; 85,3) apresentaram aumento (> P95) da espessura médio-intimal da carótida. Nos pacientes com hipertensão arterial estágios I e II, 90,9% apresentaram aumento da espessura médio-intimal da carótida. O estado nutricional, a gordura corporal e os exames laboratoriais não apresentaram associação com o aumento da espessura médio-intimal da carótida. Após ajuste multivariado, apenas a puberdade (RP = 1,30; p = 0,037) e a hipertensão arterial estágios I e II (RP = 1,42; p = 0,011) mostraram-se independentemente associados à alteração da espessura médio-intimal da carótida. Conclusão: A prevalência do aumento da espessura da carótida foi elevada em crianças e adolescentes com doença renal crônica. A puberdade e a hipertensão arterial mostraram-se independentemente associadas ao aumento da espessura médio-intimal da carótida. Keywords: Chronic kidney disease, Cardiovascular diseases, Carotid intima-media thickness, Adolescents, Children, Palavras-chave: Insuficiência renal crônica, Doenças cardiovasculares, Espessura intima-média carotídea, Adolescentes, Crianças
وصف الملف: text/html
تدمد: 0021-7557
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f12a511d8d78b3a59d897f28d71d29Test
https://doi.org/10.1016/j.jped.2018.06.010Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....16f12a511d8d78b3a59d897f28d71d29
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00217557