Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)
| العنوان: | Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON) |
|---|---|
| المؤلفون: | Lorena Vilhena de Moraes, João Felício Abrahão Neto, Maria Clara Neres Iunes de Oliveira, Fernanda de Souza Parente, Wanderson Maia da Silva, Karem Miléo Felício, Valéria Suênya Galvão Leal, Norberto Jorge Kzan de Souza Neto, Gabriela Nascimento de Lemos, Fabrício de Souza Resende, Melissa de Sá Oliveira Dos Reis, Nivin Mazen Said, João Soares Felício, Vitória Teixeira de Aquino, Hana Andrade de Rider Britto, Manuela Nascimento de Lemos, Isabel Jane Campos Lobato, Lilian de Souza D’Albuquerque Silva, Angélica Leite de Alcântara, Pedro Celeira Cortez, Ícaro José Araújo de Souza, Natércia Neves Marques de Queiroz, Daniela Lopes Gomes, Ana Carolina Contente Braga de Souza, Pedro Paulo Freire Piani, Franciane Trindade Cunha de Melo |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, HbA1c, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Renal function, vitamin D, Glycemic Control, Gastroenterology, Diseases of the endocrine glands. Clinical endocrinology, albuminuria, Excretion, Endocrinology, Risk Factors, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Vitamin D and neurology, Humans, Diabetic Nephropathies, Prospective cohort study, Original Research, Aged, Glycemic, Glycated Hemoglobin, diabetes, business.industry, Middle Aged, RC648-665, Vitamin D Deficiency, medicine.disease, Population based study, Cross-Sectional Studies, Albuminuria, epidemiology, Female, medicine.symptom, business, Brazil |
| الوصف: | BackgroundThe effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified.ObjectiveEvaluate the relationship between 25-hydroxy-vitamin D [25(OH)D], HbA1c, and albuminuria in Diabetes Mellitus (DM).Patients and MethodsCross-sectional study with 1576 individuals with DM who had 25(OH)D, HbA1c, and albuminuria levels measured. Patients with abnormal creatinine levels were excluded, in order to avoid interference on VD levels by impaired kidney function.ResultsPatients with HbA1c ≥7% had lower 25(OH)D when compared to patients with HbA1c vs 28.1 ± 9.9 ng/ml, p = 0.003) and 25(OH)D levels seems to predict 1.5% of HbA1c behavior. The 25(OH)D concentrations in patients with normoalbuminuria were higher than the levels observed in those with micro or macroalbuminuria (29.8 ± 9.0 vs 26.8 ± 8.6 and 25.1 ± 7.6, respectively, p = 0.001), patients who had 25(OH)D ConclusionOur study found an association between vitamin D levels, HbA1c and DKD. Additionally, our data suggest that the association between urinary albumin excretion and vitamin D levels is independent of glycemic control in patients with diabetes. Even though our patients presented normal creatinine levels, it is necessary further prospective studies to confirm if this association precedes or not the loss of renal function. |
| تدمد: | 1664-2392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16eb57a4cce646ac16594785c4014f20Test https://doi.org/10.3389/fendo.2021.723502Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....16eb57a4cce646ac16594785c4014f20 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
|---|