A Fully Functional Proopiomelanocortin/Melanocortin-1 Receptor System Regulates the Differentiation of Human Scalp Hair Follicle Melanocytes
| العنوان: | A Fully Functional Proopiomelanocortin/Melanocortin-1 Receptor System Regulates the Differentiation of Human Scalp Hair Follicle Melanocytes |
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| المؤلفون: | Söbia Kauser, Desmond J. Tobin, Karin U. Schallreuter, Christopher Lawrence Gummer, Anthony J. Thody |
| المصدر: | Endocrinology. 146:532-543 |
| بيانات النشر: | The Endocrine Society, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, endocrine system, medicine.medical_specialty, Pro-Opiomelanocortin, Nerve Tissue Proteins, Human skin, Melanocyte, Biology, Neuroendocrine Secretory Protein 7B2, chemistry.chemical_compound, Endocrinology, Adrenocorticotropic Hormone, Melanocyte differentiation, Proopiomelanocortin, Internal medicine, medicine, Humans, RNA, Messenger, Cells, Cultured, Scalp, integumentary system, Cell Differentiation, Middle Aged, Hair follicle, alpha-Melanocyte-stimulating hormone, Pituitary Hormones, Proprotein Convertase 2, medicine.anatomical_structure, Proprotein Convertase 1, chemistry, alpha-MSH, biology.protein, Melanocytes, Female, Melanocortin, Hair Follicle, Receptor, Melanocortin, Type 1, hormones, hormone substitutes, and hormone antagonists, Melanocortin 1 receptor |
| الوصف: | The proopiomelanocortin (POMC)-derived peptides, ACTH and alpha-MSH, are the principal mediators of human skin pigmentation via their action at the melanocortin-1 receptor (MC-1R). Recent data have demonstrated the existence of a functionally active beta-endorphin/mu-opiate receptor system in both epidermal and hair follicle melanocytes, whereby beta-endorphin can regulate melanogenesis, dendricity, and proliferation in these cells. However, a role for ACTH and alpha-MSH in the regulation of the human follicular pigmentary unit has not been determined. This study was designed to examine the involvement of ACTH and the alpha-MSH/MC-1R system in human follicular melanocyte biology. To address this question we employed RT-PCR and immunohisto/cytochemistry, and a functional role for these POMC peptides was assessed in follicular melanocyte cultures. Human scalp hair follicle melanocytes synthesized and processed POMC. ACTH and alpha-MSH in association with their processing enzymes and MC-1R are expressed in human follicular melanocytes at the message level in vitro and at the protein level both in situ and in vitro. The expression of the POMC/MC-1R receptor system was confined only to subpopulations of poorly and moderately differentiated melanocytes. In addition, functional studies revealed that ACTH and alpha-MSH are able to promote follicular melanocyte differentiation by up-regulating melanogenesis, dendricity, and proliferation in less differentiated melanocyte subpopulations. Thus, these findings suggest a role for these POMC peptides in regulating human hair follicle melanocyte differentiation. |
| تدمد: | 1945-7170 0013-7227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dc4581848dfc504b03859490d3cebaTest https://doi.org/10.1210/en.2004-1145Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....16dc4581848dfc504b03859490d3ceba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457170 00137227 |
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